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44 Cards in this Set
- Front
- Back
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Collagen Binding Protein |
S.aureus Nearly identical to CFA, but A region binds collagen. |
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FnbpA |
S.aureus
Binds fibronectin using repeat units and fibrinogin using A domain.
IgG Antibodies recognize these domains after they bind these host ECM components, leading to rapid platlet activation |
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CFA |
S.aureus
Clumping factor A
Binds fibrinogen with A region Serine/Aspartate repeat region forms a stalk that extends from the surface. |
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Vsp33 |
B.hermsii
expressed in tick (23). Needed for transmission to mammal. |
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ProteinA |
S.aureus
Can be anchored due to LPXTG motif.
Binds Fc receptor preventing opsinophagocytosis.
Can interact with B cell receptor on surfaces of B cells to result in apoptosis of B cell (30-50%). Target B cell populations in spleen and peritonal. |
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BBK32 |
B.burgdoferi
Surface lipoprotein which binds fibronectin. Maximally expressed 3-4 days after tick attachment.
Allows invasion of CNS cells and fibroblasts via a B sheet zipper mechanism. |
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VlsE |
B.burgdoferi
Functions like OspC, but varies antigenically by segmental gene conversion.
Found on liniear lp28 plasmids.
10^30 sequence variations possible! |
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ERPS |
B.burgdoferi
Binds factor H to prevent complement. Regulated by temp and QS.
Many ERPS(17) so it can express in a wide range of hosts. |
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CRASP |
B.burgdoferi
Binds factor H to prevent complement. Regulated by pH (tick saliva pH 10)
Complement regulator aquiring surface protein. |
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Vsp7+8 |
B.burgdoferi
Expressed in mammal (37). Needed for transmission to tick. |
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DbpA |
B.burgdoferi
Decorin binding protein. Binds decorin associated with collagen in joints.
Immune withDbpA- no dissemination occurs. |
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OspB |
B.burgdoferi
OspB expression is induced in tick host.
KO- unable to adhere to tick midgut. |
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OspA |
B.burgdoferi
Expression induced in tick host. Plays a protective role of integral membrane proteins.
KO- unable to attach to tick midgut |
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OspC |
B.burgdoferi
Upregulated during tick feeding. Binds Salp15 in tick saliva, which prevents antibiody mediated killing. |
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PhoQ |
S.typhimirium
Histidine kinase in a 2 component system. Repressed state: Mg binds pocket Actice state: antimicrobial peptide binds pocket triggering conformational change and dimerization, leading to autophosphorylation. |
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PhoP |
S.typhimirium
Response reglator. Once phosphorylated can turn on expression of pagP |
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pagP |
S.typhimirium
Under control of PhoQ/P. Encodes a phospholipase palmitoyltransferase which puts a palmitoyl group on lipidA making it more resistant to pepetides. |
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fibrillarin |
C.trachonomis
Present at 3 fold higher levels in occular specific strains. Tissue tropism. |
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KatE |
Leptospira
Catalase needed for leptospira survival in presence of H202.
KO- does not cause infection in mice. |
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Loa22 |
Leptospira
Lipoprotein found on surface, required for virulence. |
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What disease does T.pallidum cause |
Syphillus |
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What disease does B.burdoferi cause? |
Lyme disease |
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What disease does B.hermsii cause |
Relapsing fever
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Generation time of T.pallidum |
33h
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Vector for B.burdoferi |
Ixodes tick |
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Vector for B.hermsii |
O.hermsii |
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RosA/RosB |
Yersinia spp.
Efflux pump/potassium antiporter. Leads to acidification of the cytoplasm preventing antibacterial peptides from interacting with DNA |
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PBPs |
Catalyze cross linking of D-ala-D-ala peptide side chains |
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B-lactam antibioitcs |
Irreversibly inactivate PBPs |
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Polymyxins |
Alter cytoplasmic membrane of gram negative pathogens.
Positively charged, amphipathic molecules which disrupt IM and OM. Cause cellular leakage and death |
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Streptomycin |
changes shape of 30s rRNA and causes mRNA to be read incorrectly |
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Tetracycline |
interferes with tRNA antibodon reading of mRNA |
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Erythromycin |
binds 50s rRNA and prevents movement along mRNA |
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Chloramphenicol |
binds 50s rRNA and inhibits formation of peptide bond |
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quinolones |
inhibit bacterial DNA transcription
form a complex with DNA gyrase and topiosomerse IV |
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sulfonamides |
block synthesis of tetrahydrofolate |
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How often do adaptive mutations occur |
10^4 - 10^5 bacteria
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LAra4N |
Salmonella
Can be added to lipidA to increase charge and lower affinity for polymyxins |
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ABC superfamily |
Gram positive and gram negative. Use ATP to pump out drugs |
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MFS |
Gram postive and gram negative. Use H+ to pump out drugs |
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MATE |
Grame positive only. Uses Na+H+ to pump out drugs |
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SMR |
Gram positive only. Use H+ to pump out drugs |
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RND |
gram negative only. Use H+ to pump out drugs |
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Good luck |
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