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9 Cards in this Set
- Front
- Back
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Beta lactam |
Works against gram + (some -) by disrupting peptidoglycan |
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Carbapenem |
B-lactam, derivative of thienamycin, broad spectrum, resistant to most b-lactamase, IV only |
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Aminoglycosides |
Primarily aerobic anti-g-, interfere w proof reading process for aa-trna (30s), cidal, not oral |
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Tetracycline |
30s prevents trna into a site, broad, oral, detrimental environmental impact |
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Macrolides |
Static, g+, 50s, long half life, accumulates in euk cells |
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Oxazolidinones |
Fully synthetic, binds to Rrna on a side of ptc, iv, oral, static, g+ and tb spectrum |
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Mechanisms of resistance |
Altered target site, qltered transport and drug inactivation |
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B lactam resistance |
Low affinity intrinisic PBPs, Mutations in porin genes of g- Dec in perm to b lactam Drug inactivation by b-lactamase Can be counteracted w blactase inhibitors |
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Linezolid resist |
Uoreg of abc transporters (efflux) rrna mutations to two rproteins (uL3+4) Mutations to rrnamutations to two rproteins (uL3+4)Modifications of rrna(23s methylases) (cfr Gene) Modifications of rrna(23s methylases) (cfr Gene) |
