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12 Cards in this Set
- Front
- Back
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Q. Polio Takes How long to kill? Why is that bad?
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5-10hr to kill cell therefore no time for cell to make interferon, 25-100k progeny/cell
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Q. 2 Polio Symptom?
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Parakytic poliomyelitis, 10% develop GI problems.
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Q. What does the +sense do for polio in regards to replication?
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+Sense, functions to bind the ribosome since there is no cap, the enzyme for polio that cleaves a protein of the ribosome is so that it will halt translation and then the cell’s ribosome is only recognizing IRES on the virus & replicates that
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Q. What happens while everything accumulates during the replication process of Polio?
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As everything accumulates the proteins self assemble into capsids and put a piece of +sense RNA inside, The cell begins to fill up with assembled virus progeny until the cell becomes so full it BURSTS!!!!! And releases 100,000 of progeny viruses!.
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Q. Hep A causes infection where?
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Causes acute infection of liver by attacking hepatocytes they have receptor for HepA
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Q. In what population is West Nile Virus worst in?
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Elderly
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Q. In Ebola what protein is used for attachment to cells?
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GP protein
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Q. What are the stages of viral pneumonia of influenza?
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viral pneumonia (seen in 1918 H1N1 flu)> infects pneumocytes that make surfactant> body responds with cytokines causing inflammation> results in hemorrhaging> therefore there are more deaths in those with stronger immune function!
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Q. What does H bind to in the function of influenza?
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H binds to neuramic acid in saliva – N(Enzyme Neurominidase) cleaves the bond between H and neuramic acid (continue to bind and get broke apart until the H finally reaches the cell)
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Q. Explain the cold addapted treatment in Influenza?
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select the virus then grow it so it only likes a certain temperature and then it will only replicate in the upper respiratory tract- gives a good immune response but has the capability of adapting
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Q. What does amantidine do? What are the side effects>
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Blocks the pH change
Side effects: Nausea, depression, psychosis, seizure, confusion, hallucinations |
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Q. Primary viral pneumonia causes what? Is it the worst virus to have?
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Cause cytokine storm. Yes.
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