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15 Cards in this Set
- Front
- Back
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how is transmission of neisseria meningitidis?
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close contact - either direct contact from person to person or drop of nasopharyngeal secretion
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Meningitis is commonly caused by which serogroups of N. Meningitidis?
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A, B, C, Y, X, W-135
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True or False : N. gonorrhoeae are encapsulated
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False - they do not have the gene for capsule - they have plasmids.
N. meningitidis have capsule |
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What is meningococcal virulence determined by?
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- genome plasticity
- HGT - antigenic variation |
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How are meningococci internalized?
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by non-ciliated mucosal cells - colonize in upper resp tract - enter the submucosa and invade BS
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slow bac multiplication of N. meningitidis causes?
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local infection of meninges
rarely - joints or pericarditis |
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rapid bac multiplication in bs of n. meningitidis causes?
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- petichiae
- purpura - DIC - disseminated intravascular coagulation |
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What is the function of PorA and PorB? Where are they located and on which bacterium?
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function: activate immune cells; induce formation of bacterial antibodies
located: outer membrane of neisseria |
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What is fHbp? Why is it important in neisseria meningitis?
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outer membrane protein - included in 2 vaccines
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What are opacity associated proteins?
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Opa and Opc. Bind to integrins on hosr cell. (stimulates engulfment)
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IgA protease, iron extraction and lipooligosaccaride are all examples of
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virulence factors of n. meningitidis.
IgA protease - cleaves IgA to decrease mucosal immunity n. meningitidis can extract iron from human LOS - endotoxin determines immunitype |
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describe gram - endotoxic shock.
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endotoxin reacts with monocytes, neutrophils. interleukins are released (tnf, il1,6,8). cytokines initiate imflammation which damages every organ.
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The most lethal form of septicemia experienced by humans is caused by?
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neisseria meningitidis
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bleeding into the adrenal gland or waterhouse friderichsen syndrome is caused by which bac.,
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neisseria meningitidis. causes acute adrenal gland insufficiency
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meningitis infection typically begins where?
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choroid plexus of ventricles
then they enter subarachnoid spc.bacterial growth and inflammation occur |
