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60 Cards in this Set
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Dermatitis
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A group of inflammatory puritic skin dosorders. Etiology: allergy (usually type 4 hypersensitivity), chemical injury, or infection.
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p. 322
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What are the 3 main etiologies of Dermatitis
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allergy (usually type 4 hypersensitivity), chemical injury, and infection
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p. 322
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What is atopic dermatitis (escema)
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Puritic eruption, mainly on flexor surfaces. Often associated w/other atopic diseases (asthma, allergic rhinitis).
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p. 322
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What is atopic dermatitis associated with? (2)
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asthma, allergic rhinitis
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p. 322
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What do you call a puritic eruption, mainly on flexor surfaces.
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atopic dermatitis
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p. 322
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Allergic contact dermatitis
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Type IV hypersensitivity reaction that follows exposure to allergen (poison ivy, poison oak, nickel, rubber, chemicals). Lesions occur at site of contact.
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p. 322
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What is the name for the type IV hypersensitivity reaction of the skin that follows exposure to allergen
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Allergic contact dermatitis
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p. 322
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Where is the lesion following exposure in allergic contact dermatitis
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the site of contact
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p. 322
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What is psoriasis
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Epidermal hyperplasia (acanthosis) with parakeratotic scaling (nuclei still in stratum corneum) espcially on the knees and elbos. Increased stratum spinosum. Decreased stratum granulosum. Auspitz sign.
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p. 322
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What are the histologic features of psoriasis (4)?
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Epidermal hyperplasia: nuclei still in stratum corneum. Increased stratum spinosum. Decreased stratum granulosum
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p. 322
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What skin condition presents with Auspitz sign?
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Psoriasis
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p. 322
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What skin condition is characterized by Epidermal hyperplasia: nuclei still in stratum corneum. Increased stratum spinosum. Decreased stratum granulosum
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Psoriasis
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p. 322
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What skin condition is often found on knees and elbows
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Psoriasis
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p. 322
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What skin condition presents with parakeratotic scaling?
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Psoriasis
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p. 322
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What is parakeratotic scaling?
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nucli still in stratu corneum.
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p. 322
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What is dermatitis herpetiformis
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Pruritic papules and vesicles. Associated with celiac disease.
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p. 322
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What skin condition is associated with celiac disease?
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dermatitis herpetiformis
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p. 322
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What skin condition presents with pruritic papules and vesicles?
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dermatitis herpetiformis
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p. 322
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What is Lichen planus
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Pruritic, purple, polygonal papules; infiltrate of lymphocytes at dermoepidermal junction
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p. 322
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What skin condition presents with pruritic, purple, polygonal papules
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Lichen planus
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p. 322
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What skin condition is histologically characterized by infiltrate of lymphocytes at dermoepidermal junction
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Lichen planus
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p. 322
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What is erythema multiforme associated with (4 conditions). What is the clincial presentation (4) features.
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Associated with infectons, drugs, cancers and autoimmune disease. Presets with mutiple types of lesions, including macules, papules, vesicles, and target leisons (red papules with a pale center).
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p. 322
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What skin condition presents with macules, papules, vesicles, and target leisons
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erythema multiforme
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p. 322
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What skin condition is associated with infectons, drugs, cancers and autoimmune disease
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erythema multiforme
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p. 322
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What is the major form of erythema multiforme?
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Stevens-Johnson syndrome
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p. 322
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What are the characterizes Stevens-Johnson syndrome (5)?
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high fever, bulla formation and necrosis, ulceration of the skin and a high mortality
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p. 322
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What type of skin syndrom is Stevens-Johnson syndrome
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Erythema multiforme
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p. 322
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What is Seborrheic keratosis?
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Flat, pigmented squamous epithelial proliferation with keratin-filled cysts (horn cysts). Benign.
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p. 322
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What skin condition presents with flat, pigmented squamous epithelial proliferation with keratin-filled cysts (horn cysts)
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Seborrheic keratosis
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p. 322
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What is the prognosis for Seborrehic keratosis?
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Good, it's benign.
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p. 322
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What is Actinic keratosis?
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Caused by suun exposure. Small, rough, erythematous or brownish papules. Premalignant lesion. Risk of carcinoma is proportional to epithelial dysplasia.
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p. 322
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How does Actinic keratosis present clinically?
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Small, rough erythematous or brownish papules.
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p. 322
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Where is Actinic keratosis on the spectrum of malignant transformation?
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Pre-malignant
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p. 322
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What is the cause of actinic keratosis
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Sun exposure
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p. 322
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What skin condition does sun exposure lead to?
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actinic keratosis
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p. 322
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What determines the risk of pregression to carcinoma in actinic keratosis?
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risk is proportional to epithelial dysplasia
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p. 322
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What is keloid
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Tumor of connective tissue elemets of dermis that causes raised, thickened scars. Follows trauma to skin, especically in African-Americans
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p. 322
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What skin condition are African-Americans pre-disposed to
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keloid
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p. 322
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What is the clinical presentation of keloid?
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Tumor of raised thickened scars
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p. 322
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What skin condition presents with a tumor of raised thickend scars
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keloid
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p. 322
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What skin condition follows trauma to skin?
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keloid
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p. 322
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What a tumor of connective tissue elemets of dermis called
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keloid
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p. 322
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What are the histologic features of keloid
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tumor of connective tissue elemts of demis.
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p. 322
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Bullous pemphigoid
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Autoimmune disorder with IgG antibody against epidermal basement membrane (linear immunoflouresce). Similar to but less sever than pemphigus vultgaris - affects skin but spares orgal mucosa.
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p. 322
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What skin condition is an autoimmune disorder with IgG antibody against epidermal basement membrane
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Bullous pemphigoid
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p. 322
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How would you test for bullous pemphigoid
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Use immunoflourescent anti-human antibodies. Look for a linear pattern along the epidermal basement membrane.
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p. 322
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What skin disorder does a linear immunoflourescent pattern along the basement membrane point to?
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bullous pemphigoid
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p. 322
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What is the clinical presentation of bullous pemphigoid?
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affects skin but spares oral mucosa.
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p. 322
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What is the difference between bullous pemphigoid and pemphigus vulgaris
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bullous pemphigoid affects the skin but spares the oral mucosa, pemphigus vulgaris invovles the oral mucosa and skin
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p. 322
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What ar two autoimmune skin disorders?
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bullous pemphigoid and pemphigus vulgaris
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p. 322
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What is pemphigus vulgaris?
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Potentially fatal autoimmune skin disorder. Intradermal bullae involving the oral mucosa and skin.
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p. 322
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What are the histologic findings in pemphigus vulgaris?
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acanthosis (breakdown of epithelial cell-to-cell junctions), IgG antibody agaist epidermal cell surface (immunofluorescence througout epidermis).
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p. 322
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What is the immunoflourescence presentation of pemphigus vulgaris vs. bullous pemphigoid
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Pemphigus vulgaris has immunofluorescence througout epidermis, bullous pemphigoid only has immunoflourescence along the epidermal basement membrane (linear pattern).
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p. 322
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What skin disease presents with acanthosis (breakdown of epithelial cell-to-cell junctions), IgG antibody agaist epidermal cell surface (immunofluorescence througout epidermis).
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Pemphigus vulgaris
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p. 322
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What skin condition presents with numerous crusted, denuded and weepy erythematous plaques all over the body and vesicles on the gingiva
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Pemphigus vulgaris
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fig 63
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What skin condition presents with erythematous plaques contiguous with large bullae
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Bullous pemphigoid
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fig 64
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What does the patient with pemphigus vulgaris look like? (3 features)
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numerous crusted, denuded and weepy erythematous plaques all over the body and vesicles on the gingiva
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fig 64
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What is the physical finding in the patient with bullous pemphigiod
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erythematous plagues contiguous with large bullae
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fig 63
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What is the type of autoantibody seen in bullous pemphigiod and pemphigus vulgaris
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IgG
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p. 322
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Which condition is more sever bullous pemphigoid or pemphigus vulgaris
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pemphigus vulgaris
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p. 322
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