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60 Cards in this Set

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Dermatitis
A group of inflammatory puritic skin dosorders. Etiology: allergy (usually type 4 hypersensitivity), chemical injury, or infection.
p. 322
What are the 3 main etiologies of Dermatitis
allergy (usually type 4 hypersensitivity), chemical injury, and infection
p. 322
What is atopic dermatitis (escema)
Puritic eruption, mainly on flexor surfaces. Often associated w/other atopic diseases (asthma, allergic rhinitis).
p. 322
What is atopic dermatitis associated with? (2)
asthma, allergic rhinitis
p. 322
What do you call a puritic eruption, mainly on flexor surfaces.
atopic dermatitis
p. 322
Allergic contact dermatitis
Type IV hypersensitivity reaction that follows exposure to allergen (poison ivy, poison oak, nickel, rubber, chemicals). Lesions occur at site of contact.
p. 322
What is the name for the type IV hypersensitivity reaction of the skin that follows exposure to allergen
Allergic contact dermatitis
p. 322
Where is the lesion following exposure in allergic contact dermatitis
the site of contact
p. 322
What is psoriasis
Epidermal hyperplasia (acanthosis) with parakeratotic scaling (nuclei still in stratum corneum) espcially on the knees and elbos. Increased stratum spinosum. Decreased stratum granulosum. Auspitz sign.
p. 322
What are the histologic features of psoriasis (4)?
Epidermal hyperplasia: nuclei still in stratum corneum. Increased stratum spinosum. Decreased stratum granulosum
p. 322
What skin condition presents with Auspitz sign?
Psoriasis
p. 322
What skin condition is characterized by Epidermal hyperplasia: nuclei still in stratum corneum. Increased stratum spinosum. Decreased stratum granulosum
Psoriasis
p. 322
What skin condition is often found on knees and elbows
Psoriasis
p. 322
What skin condition presents with parakeratotic scaling?
Psoriasis
p. 322
What is parakeratotic scaling?
nucli still in stratu corneum.
p. 322
What is dermatitis herpetiformis
Pruritic papules and vesicles. Associated with celiac disease.
p. 322
What skin condition is associated with celiac disease?
dermatitis herpetiformis
p. 322
What skin condition presents with pruritic papules and vesicles?
dermatitis herpetiformis
p. 322
What is Lichen planus
Pruritic, purple, polygonal papules; infiltrate of lymphocytes at dermoepidermal junction
p. 322
What skin condition presents with pruritic, purple, polygonal papules
Lichen planus
p. 322
What skin condition is histologically characterized by infiltrate of lymphocytes at dermoepidermal junction
Lichen planus
p. 322
What is erythema multiforme associated with (4 conditions). What is the clincial presentation (4) features.
Associated with infectons, drugs, cancers and autoimmune disease. Presets with mutiple types of lesions, including macules, papules, vesicles, and target leisons (red papules with a pale center).
p. 322
What skin condition presents with macules, papules, vesicles, and target leisons
erythema multiforme
p. 322
What skin condition is associated with infectons, drugs, cancers and autoimmune disease
erythema multiforme
p. 322
What is the major form of erythema multiforme?
Stevens-Johnson syndrome
p. 322
What are the characterizes Stevens-Johnson syndrome (5)?
high fever, bulla formation and necrosis, ulceration of the skin and a high mortality
p. 322
What type of skin syndrom is Stevens-Johnson syndrome
Erythema multiforme
p. 322
What is Seborrheic keratosis?
Flat, pigmented squamous epithelial proliferation with keratin-filled cysts (horn cysts). Benign.
p. 322
What skin condition presents with flat, pigmented squamous epithelial proliferation with keratin-filled cysts (horn cysts)
Seborrheic keratosis
p. 322
What is the prognosis for Seborrehic keratosis?
Good, it's benign.
p. 322
What is Actinic keratosis?
Caused by suun exposure. Small, rough, erythematous or brownish papules. Premalignant lesion. Risk of carcinoma is proportional to epithelial dysplasia.
p. 322
How does Actinic keratosis present clinically?
Small, rough erythematous or brownish papules.
p. 322
Where is Actinic keratosis on the spectrum of malignant transformation?
Pre-malignant
p. 322
What is the cause of actinic keratosis
Sun exposure
p. 322
What skin condition does sun exposure lead to?
actinic keratosis
p. 322
What determines the risk of pregression to carcinoma in actinic keratosis?
risk is proportional to epithelial dysplasia
p. 322
What is keloid
Tumor of connective tissue elemets of dermis that causes raised, thickened scars. Follows trauma to skin, especically in African-Americans
p. 322
What skin condition are African-Americans pre-disposed to
keloid
p. 322
What is the clinical presentation of keloid?
Tumor of raised thickened scars
p. 322
What skin condition presents with a tumor of raised thickend scars
keloid
p. 322
What skin condition follows trauma to skin?
keloid
p. 322
What a tumor of connective tissue elemets of dermis called
keloid
p. 322
What are the histologic features of keloid
tumor of connective tissue elemts of demis.
p. 322
Bullous pemphigoid
Autoimmune disorder with IgG antibody against epidermal basement membrane (linear immunoflouresce). Similar to but less sever than pemphigus vultgaris - affects skin but spares orgal mucosa.
p. 322
What skin condition is an autoimmune disorder with IgG antibody against epidermal basement membrane
Bullous pemphigoid
p. 322
How would you test for bullous pemphigoid
Use immunoflourescent anti-human antibodies. Look for a linear pattern along the epidermal basement membrane.
p. 322
What skin disorder does a linear immunoflourescent pattern along the basement membrane point to?
bullous pemphigoid
p. 322
What is the clinical presentation of bullous pemphigoid?
affects skin but spares oral mucosa.
p. 322
What is the difference between bullous pemphigoid and pemphigus vulgaris
bullous pemphigoid affects the skin but spares the oral mucosa, pemphigus vulgaris invovles the oral mucosa and skin
p. 322
What ar two autoimmune skin disorders?
bullous pemphigoid and pemphigus vulgaris
p. 322
What is pemphigus vulgaris?
Potentially fatal autoimmune skin disorder. Intradermal bullae involving the oral mucosa and skin.
p. 322
What are the histologic findings in pemphigus vulgaris?
acanthosis (breakdown of epithelial cell-to-cell junctions), IgG antibody agaist epidermal cell surface (immunofluorescence througout epidermis).
p. 322
What is the immunoflourescence presentation of pemphigus vulgaris vs. bullous pemphigoid
Pemphigus vulgaris has immunofluorescence througout epidermis, bullous pemphigoid only has immunoflourescence along the epidermal basement membrane (linear pattern).
p. 322
What skin disease presents with acanthosis (breakdown of epithelial cell-to-cell junctions), IgG antibody agaist epidermal cell surface (immunofluorescence througout epidermis).
Pemphigus vulgaris
p. 322
What skin condition presents with numerous crusted, denuded and weepy erythematous plaques all over the body and vesicles on the gingiva
Pemphigus vulgaris
fig 63
What skin condition presents with erythematous plaques contiguous with large bullae
Bullous pemphigoid
fig 64
What does the patient with pemphigus vulgaris look like? (3 features)
numerous crusted, denuded and weepy erythematous plaques all over the body and vesicles on the gingiva
fig 64
What is the physical finding in the patient with bullous pemphigiod
erythematous plagues contiguous with large bullae
fig 63
What is the type of autoantibody seen in bullous pemphigiod and pemphigus vulgaris
IgG
p. 322
Which condition is more sever bullous pemphigoid or pemphigus vulgaris
pemphigus vulgaris
p. 322