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14 Cards in this Set

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pathogenisis reliant on several virulence factors is stb ___
multifactorial
What are the two ways bacteria can cause disease?
chemical/molecular mechanisms that damage host

triggering a chronic inflammatory response
Define invasiveness
ability to spread within host
Define bacteremia
presence of bacteria in the blood
Define septicaemia
evidence that bacteria are multiplying in the blood
What are the seven important Salmonella virulence factors?
endotoxin in LPS layer (fever)
enterotoxin (diarrhea)
Type I fimbriae (adherence)
Cytotoxin (adherence; inhibits host cell protein synthesis)
Flagellum
VI antigen (adherence; inhibits phagocyte killing)
O antigen (inhibits phagocyte killing)
What does the Salmonella enterotoxin cause?
diarrhea
What does the Salmonella endotoxin cause? Where is it located?
fever. LPS layer
What is the function of the Salmonella O and VI antigens?
inhibition of phagocyte killing
What does the Salmonella cytoxin do?
inhibits host cell protein synthesis; adherence
What are the Salmonella Type I fimbriae for?
adherence
What are Koch's postulates used for?
To determine whether a relationship exists between a particular pathogen and disease.
What are Koch's postulates?
1) present in all cases of disease
2) must be isolated from infected organism and cultivated purely
3) this culture when inoculated into animals must produce the disease
4) must be able to re-isolate from inoculated animals, and compare to original
What are Koch's molecular postulates?
- gene/factor must be present in pathogenic strains only
- knock-out should reduce virulence
- introduce cloned gene(s), should render avirulent strain virulent
- genes must be expressed at some point during infection
- antibody agains virulence factor should offer some protection