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34 Cards in this Set
- Front
- Back
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Allergic Rxn: IgE mediated
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IgE attach to mast cells --> release histamine
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Cytotoxic/Cytolytic: IgG or IgM mediated
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blood type, Rh+ (IgG crosses placenta)
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Serum Sickness: IgG mediated
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too many immune complexes from precipitation; phagocytes can't keep up
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Cell-Mediated Delayed: T cell mediated
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Th cells increase after 1st exposure; Th release cytokines --> mark for macrophage destruction, rash
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Activation of Macrophages by Th
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MHII + CD4 call forth Th; release cytokines --> activate lysozymes to digest microbe inside macrophage
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B cells made in bone marrow
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carry IgM or IgD on surface
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T cells made in thymus gland
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all T cells have CD3 receptor
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Erythrocyte
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Red; carry oxygen
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Thrombocyte
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Platelets; clot
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Leukocytes
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White; defend and confer immunity
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Granulocyte
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Eosinophil, Basophil, Neutrophil
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Eosinophil
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allergies; protect against parasitic worms
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Basophil
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release histamine; inflammation
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Neutrophil
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phagocytosis; majority of circulating leukocytes
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Agranulocyte
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Monocyte, Macrophage
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Monocyte
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circulate in blood
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Macrophage
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in tissues, must be activated by T cells to break down microbe
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Granuloma
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large # of fused macrophages that localize infection
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Lymphocyte
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T, B, Natural Killer cells
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Chemokine: chemical messenger
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inflammation, attract phagocyte & lymphocyte
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Interleukin
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regulate differentiation of leukocyte (T&B) & hematopoietic stem cells
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Hematopoietin
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made in bone marrow; decides what hematopoietic stem cells become
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Tumor Necrosis Factors
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kill tumor cells
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Interferon: secreted to neighbor
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made by virus-infected cells; makes genes for anti-viral activity
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IgG: most abundant
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cross placenta, opsonization: attack to antigen then Fc freely binds to phagocytes
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IgM: 2nd most abundant
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agglutination to enhance phagocytosis
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IgA
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in mucus, saliva, breast milk; MAC
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IgD
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signal B memory to make plasma
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IgE
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allergy; binds to mast cells --> histamine
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Neutralization
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antibodies bind to antigen, block virus attachment
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Opsonization
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tag on antigen
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Precipitation
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antibody + free antigen = immune complexes
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Agglutination
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cross-linking antigens = large target
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Complement Fixation
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MAC attack
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