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8 Cards in this Set
- Front
- Back
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Cyclosporine
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Blocks T cell cytokine production by blocking NFAT transcription factor.
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FK506
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Blocks T cell cytokine production by blocking NFAT transcription factor.
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Mycophenolate mofetil/Azathioprine
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Blocks lymphocyte proliferation by blocking gunaine necleotide synth.
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Rapamycin
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Blocks lymphosyte prolif. by inhibiting IL-2 signaling.
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Corticosteroids
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Reduce inflammation by inhibiting mac cytokine secretion.
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Anti CD3 monoclonal antibody
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Depletes T cells by binding to CD 3 and causing phagocytosis or compliment activation on cell. For acute rejection.
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Anti IL-2 receptor antibody
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Inhibits T cell prolif. by blocking IL-2 binding. May also opsonize.
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CTLA4-Ig
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Inhibits t cell activation by blocking B7 sotim to binding CD28
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