Mhr Topic 21: Sprochettes And Unusual Bacteria

Front 1

T. pallidium (infection, disease, mech)

Back 1

1) Sexual contact or birth canal
2) Syphilis and congenital syphilis
3) Damage caused by prolonged DTH response.

Front 2

Syphilis life cycle

Back 2

1) Infection
2) Primary syphilis - Chancre at site of infection.
3) Secondary syphilis - Several weeks later. Rash appears, mainly on palms and soles of feet
4) Latent phase - asymptomatic. Can bounce between secondary and latent for years.
5) tertiary syphilis - not all cases get to this level. Get gumma (ganulous lesion) of skin and neuro/cardiovascular problems.

Front 3

Congenital syphilis

Back 3

Caused by T. pallidum
Fetus gets infected transplacentally. Can cause abortion. Get be born with CNS probs. congenital abnormalities, and "snuffles"

Front 4

T. Pallidum Diagnosis

Back 4

1) Rash pattern
2) Serological testing looking for Abs.

Front 5

T. pallidium shape

Back 5

Sprochette

Front 6

Borrelia burgdorferi (Infection, Disease)

Back 6

1) Lyme Disease
2) Tick bite with deer as maintanence host

Front 7

Borrelia burgdorferi shape

Back 7

Large sprochete

Front 8

Where is lyme disease endemic?

Back 8

Northeast.

Front 9

Lime disease life cycle

Back 9

Tick causes infection:
1) First stage - Flu like symptoms + target rash
2) Second stage - Spreads via lymph or blood. Causes arthritis, cardiac and neuro probs.
3) Third stage - Chronic arthritis and CNS disease.

Front 10

Borrelia burgdorferi diagnosis

Back 10

1) Target shaped rash
2) Serological testing.

Front 11

Borrelia recurrentis

Back 11

Sprochete, Vector born, causes relapsing fever.

Front 12

Leptospira interrogans

Back 12

Sprochette, disease transmitted via food or water contamination with rat feces or through skin abraisions. Prevention is rodent control.

Front 13

Clinical definition of atypical pneumonia

Back 13

1) Gradual onset
2) Little, clear sputum
3) Patchy pneumonia, not lobular.

Front 14

Mycoplasma cell membrane characteristics

Back 14

No cell wall (therefore very pleiomorphic and penecillin resistant)
Lipid membrane contains sterols

Front 15

Mycoplasma pneumoniae Diagnosis

Back 15

Culture grows slowly, looks like fried eggs.
Serologic - Ab titer rise
Cold agglutinins - autoimmune antibody associated with this organism.

Front 16

Mycoplasma pneuomiae Disease

Back 16

"walking pneumonia", not sever if not complicated. Gradual onset with skant cough. Patchy interstitial infiltrate

Front 17

Mycoplasma infection and disease mech.

Back 17

1)Person to person via respiratory droplets.
2) Bind between cilliated epithelial cells and produce H2O2. Damage cilia.

Front 18

Ureaplasma

Back 18

Urogenital mycoplasma, produces urease

Front 19

M. hominis

Back 19

Urogenital mycoplasma

Front 20

Chlamidia cell membrane characteristics

Back 20

Looks like gram (-) with dual lipid bilayer and has LPS but has no peptidoglycan. Makes it resistant to penicillin.

Front 21

Chlamydia life cycle

Back 21

Is an Obligate Intracellular; needs host cell ATP.
1) Elementary body phagocytosed by a host cell
2) Elementary body becomes a reticulate body.
3) Reticulate body divides repeatedly via binary fission.
4) Condense back into elemntary bodies
5) Burst cell and find more hosts.

Front 22

What cells are the primary target of clamydia?

Back 22

Epithelial cells or geneital respirator and eyes.

Front 23

D-K serotypes of Chlamydia trachomatis

Back 23

Cause urethritis or cervictitis, a mucoid discharge, and possibly conjunctivitis (adult or neonatal).
Infection caused by sex or birth canal.

Front 24

L serotypes of Chlamydia trachomatis

Back 24

More invasive STD, infection caused by sex or birth canal. Get painful papules on genitalia and lymphatic problems.

Front 25

A, B, C serotypes of Chlamydia trachomatis

Back 25

Caused by personal contact with eye. Causes Trachoma = chronic keratoconjunctivitis which can lead to blindness.

Front 26

Chlamydophila pneumoniae

Back 26

Respiratory aerosol transmission. Only in humans. Atypical pneumonia

Front 27

Chlamydophila psittaci

Back 27

Acquired from dried bird feces. Causes atypical pneumonia.

Front 28

Rickettsia life cycle

Back 28

Obligate Intracellular (needs ATP)
1) Bind via adhessions Is phagocytossed
2) lyses phagosome with PLA
3) replicates in cytoplasm
4) Mobilize actin and lyses cell with PLA.

Front 29

What does rockettsia mainly effect?

Back 29

Vasculature

Front 30

3 symptoms which indicate tick born disease

Back 30

1) high fever
2) Rash
3) Headache

Front 31

RMSF Who and when and where

Back 31

Kids usually in the summer months in south central and mid atlantic region.

Front 32

Rickettsiae rickettsii (Infection, Disease, Diagnosis)

Back 32

1) Infected by tick
2) RMSF. High fever, headache, rash, can lead to circulatory collapse
3) Rash starts on palms and travels to trunk. Rash may be absent. Serology.

Front 33

Rickettsia akari (Infection, disease, diagnosis)

Back 33

1) Mite bite
2) Eshar (thick crust) at bite site, and papulovesicular rash.
3) Via rash and serology.

Front 34

Rickettsia prowazekii (Infection, Disease, diagnosis)

Back 34

1) Only in humans. Vector is body louse.
2) Fever chills headache CNS probs vascualr colapse
3) Rash starts on trunk and radiates outward.

Front 35

Rickettsia typhus

Back 35

Similar disease to prowazeki but milder and has flea/lice vector.

Front 36

Erlichia and Anaplasma (infection, disease, diagnosis)

Back 36

1)Disease caused by ticks.
2) Causes fever, leukocytopenia, thrombocytopenia.
3) Obligate intracellular parasite which targets leukocytes. Replicates inside vacuoles; look like morulae, is diagnostic along with serology.

Front 37

Coxiella burnetti (Iinfection, Disease)

Back 37

1) Only rickettsia without an bug vector. Transmitted by inhilation, abraison, or GI.
2) Q fever. an Atypical pneumonia