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14 Cards in this Set
- Front
- Back
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Treatment of osteomylelitis?
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Bone resection and antimicrobial therapy
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Pathogenesis of hemotogenous osteomyelitis?
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Bacteremia, deposition w/in sinusoidal vein initiates inflammatory response
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Pathology of hemotogenous osteomyelitis?
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Necrosis, abscess, spread of infection to subperiosteal space, then to joint space or sinus tract to cutaneous surface
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Risk factors for hemotogenous osteomyelitis?
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Hemoglobinopathies, RES inability to phagocytose, chronic granulomatous disease of childhood, preexisting infections or IV access
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Pathophysiology of Continuous focus osteomyelitis?
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Adjacent infection of soft tissue, devitalized bone, presence of foreign bodies, boe instability
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Pathogenesis of Vascular insufficiency associated with osteomyelitis?
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Diabetes of generalized severe stherosclerotic disease, neuropathy, vasculopathy, tissue necrosis with subsequant infection
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Microbial virulence of Staph aureus?
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Intracellular survival, adherence, inflammatory response mediators, most common pathogen
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Microbial virulence of Strep and Gram negative bacilli?
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Endotoxins, acute inflammatory response mediators
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Salmonella is associated with?
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Sickle cell anemia
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Pseudomonas is associated with?
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I.V. drug users
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Pyogenic/septic Arthritis?
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monoarticular, usually hematogenous in origen, acute synovial inflammation and cartilage damage(destruction if untreaded)
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Pathogens in native joint with Pyogenic/septic Arthritis?
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early/preadolescent: S. aureus, streptococci, G-R
Adolescent and young adults: gonococus |
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Pathogens in prosthetic joint with Pyogenic/septic Arthritis?
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Early onset: S. aureus, coagulase negative staph, GNR
Late onset: CNS, Strep, GNR |
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Causes of post infectious/inflammatory arthritis?
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Deposition(bact antigen, exotoxin, immune complex, IG, comp), crystal deposition disease, foriegn body, Hemarthrosis
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