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18 Cards in this Set

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  • Back
Nonconventional Antipsychotics are the 1st line drug for what disorder
Schizophrenia
Give Medication Example of Nonconventional Antipsychotic
Aripiprazole (Abilify) & Colzapine (Clozaril)
List 1 negative attribute about Aripiprazole (Abilify)
$$$$$ Expensive
List 1 positive thing about Aripiprazole (Abilify)
Least likely to increase prolactin levels.
Nonconventional Antipsychotics Action
Acts on serotonin, adrenergic (catecholamine) & cholinergic receptors. Selectively blocks dopamine receptors in the limbic system instead of neostriatal area (preventing motor side-effects seen with 1st generation antipsychotics).
Nonconventional Antipsychotics S/E
Bonemarrow depression/Agranulocytosis RARE but serious. Requires weekly CBC/WBC 1st 6months then biweekly. Very sedating.
Olanzapine (Zyprexa) Action
blocks som serotonin receptors and dopamine receptors (D2). Antagonizes D1 & D4 receptors,serotonin 5-HT2C & 5HT3 receptors, alpha adrenergic & H1 receptors.
Olanzapine (Zyprexa) S/E
somnolence,psychomotor activation (agitation, nervousness, insomnia), dizziness, weight gain and dry mouth.
Olanzapine (Zyprexa) NSG concerns
Smoking may increase clearance by 40%. Long half-life—may be given 1 X/day—better compliance.
Quetiapine (Seroquel) ----XR form also Action
an antagonist @ multiple neurotransmitter receptors in the brain
Quetiapine (Seroquel) ----XR form also S/E
Headache, somnolence, dizziness,constipation, postural hypotension. Least likely to cause EPS.
Quetiapine (Seroquel) ----XR form also NSG Concerns
Need yearly vision exam with regular use. XR do not crush, give on empty stomach.
Ziprasidone (Geodon)
Must give with food or only 50% absorbed.
Risperidone (Risperdal) Palperidone (Invega) Risperdal Consta (IM depot form) Action of all three
Antagonist of serotonin (5HT2A) & dopamine (D2) receptors.Little potential for agranulocytosis.
Risperidone (Risperdal) Palperidone (Invega) Risperdal Consta (IM depot form) S/E of all three
Dosages slightly above recommended may cause motor disturbances. May cause orthostatic hypotension, sedation, decreased sexual interest, insomnia, coughing, back & chest pain, as well as potential for lowering seizure threshold.
Risperidone (Risperdal) Palperidone (Invega) Risperdal Consta (IM depot form) NSG Concerns for all three
Consider baseline EKG
Lab Concerns for all atypical antipsychotics
Weight, BMI, Fasting CMP for glucose, A1C, Lipid Panel. Baseline and every 6 months. DC if ANC <1000.
New Antipsychotics
Fanapt/Iloperidon & Saphis/Asenapine