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18 Cards in this Set
- Front
- Back
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Nonconventional Antipsychotics are the 1st line drug for what disorder
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Schizophrenia
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Give Medication Example of Nonconventional Antipsychotic
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Aripiprazole (Abilify) & Colzapine (Clozaril)
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List 1 negative attribute about Aripiprazole (Abilify)
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$$$$$ Expensive
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List 1 positive thing about Aripiprazole (Abilify)
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Least likely to increase prolactin levels.
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Nonconventional Antipsychotics Action
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Acts on serotonin, adrenergic (catecholamine) & cholinergic receptors. Selectively blocks dopamine receptors in the limbic system instead of neostriatal area (preventing motor side-effects seen with 1st generation antipsychotics).
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Nonconventional Antipsychotics S/E
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Bonemarrow depression/Agranulocytosis RARE but serious. Requires weekly CBC/WBC 1st 6months then biweekly. Very sedating.
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Olanzapine (Zyprexa) Action
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blocks som serotonin receptors and dopamine receptors (D2). Antagonizes D1 & D4 receptors,serotonin 5-HT2C & 5HT3 receptors, alpha adrenergic & H1 receptors.
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Olanzapine (Zyprexa) S/E
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somnolence,psychomotor activation (agitation, nervousness, insomnia), dizziness, weight gain and dry mouth.
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Olanzapine (Zyprexa) NSG concerns
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Smoking may increase clearance by 40%. Long half-life—may be given 1 X/day—better compliance.
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Quetiapine (Seroquel) ----XR form also Action
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an antagonist @ multiple neurotransmitter receptors in the brain
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Quetiapine (Seroquel) ----XR form also S/E
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Headache, somnolence, dizziness,constipation, postural hypotension. Least likely to cause EPS.
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Quetiapine (Seroquel) ----XR form also NSG Concerns
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Need yearly vision exam with regular use. XR do not crush, give on empty stomach.
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Ziprasidone (Geodon)
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Must give with food or only 50% absorbed.
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Risperidone (Risperdal) Palperidone (Invega) Risperdal Consta (IM depot form) Action of all three
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Antagonist of serotonin (5HT2A) & dopamine (D2) receptors.Little potential for agranulocytosis.
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Risperidone (Risperdal) Palperidone (Invega) Risperdal Consta (IM depot form) S/E of all three
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Dosages slightly above recommended may cause motor disturbances. May cause orthostatic hypotension, sedation, decreased sexual interest, insomnia, coughing, back & chest pain, as well as potential for lowering seizure threshold.
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Risperidone (Risperdal) Palperidone (Invega) Risperdal Consta (IM depot form) NSG Concerns for all three
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Consider baseline EKG
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Lab Concerns for all atypical antipsychotics
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Weight, BMI, Fasting CMP for glucose, A1C, Lipid Panel. Baseline and every 6 months. DC if ANC <1000.
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New Antipsychotics
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Fanapt/Iloperidon & Saphis/Asenapine
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