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122 Cards in this Set
- Front
- Back
- 3rd side (hint)
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block host cell inducing apoptosis -which viruses
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adenovirus, EBV, HepB, CMV, Marek's
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block host cell inducing apoptosis adenovirus
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E1B/E4
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p53
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block host cell inducing apoptosis EBV
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BZLF1, BALF1
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in this order, p53, caspase9
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block host cell inducing apoptosis HepB
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pX
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p53
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CD8 -MHC what type
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MHC type I
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CD4-MHC what type
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MHC type II
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helper cell to induce humoral, which type
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CD4 Th2
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hel[per cell to induce cytotixc which type
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CD4 Th1
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inhibit STAT-which viruses
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HSV, sendai, protein V, adenovirus E1A
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inhibit STAT-adenovrius
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E1A
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inhibit JAK-which viruses
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polyoma, CMV
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inhibit JAK-polyoma
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large T
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inhibit RNaseL -which virus
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SV40
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inhibit MxA-which virus
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HepB
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inhibit MxA-HepB
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capsid
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CAIV-master strain
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H2N2
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CAIV-type of vaccine
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live attenuated
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CAIV-current strain
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H3N2, H1N1
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polio Sabin-type of vaccine
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live attenuated
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mumps-type of vaccine
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live attenuated
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rubella-type of vaccine
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live attenuated
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varicella-type of vaccine`
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live attenuated
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yellow fever-type of vaccine
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live attenuated
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Trim 5 alpha-which virus
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HIV-1
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trim 5 alpha-what does it do
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binds HIV-1 capsid in monkeys
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trim 5 alpha-human?
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no idea
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trim 1
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blocks MLV
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trim 19
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blocks foamy tas replication (retrovirus)
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trim 22
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downregulate HIV-1 transcription
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which trim induced by interferon
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trim 22
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activates anti-apoptotic genes-which viruses
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CMV, Marek's
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blocks caspase 9
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EBV BALF1
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complement--innate/adaptive
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innate
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professional presenting Ag cells
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macrophages, B cells, dendrites
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which 2 types of cells are IFN gamma?
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T cells, NK cells
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What activates interferon exp?
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dsRNA
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Do IFNs activate MHC I, II, which one or both?
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both
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What is the end result of interferon activation?
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syn of antivrial proteins
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What are regulatory IFN proteins?
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IFN3, IFN7
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Which host cell protein is activated by dsRNA?
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PKR
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What are the proteins activated by IFN? (Main Pro)
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Mx, ADAR1, Irf, NO synthase , PKR, RNase L, 2'5 oligo A synthetase,
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What does Pkr do?
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Ser phosphorylates/locks elf-2alpha in complex with elf-2B and GDP, so it can't activate 40S ribosome, translation initiation
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what does RNase L and 2'5 oligo A syntheaste do?
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they oligomerize adenlyic acid and activate Rnase L, which inhibits all cellular and viral RNA
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What does Mx do?
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Mx inhibits nucleocapsid proteins from going into the Golgi or nucleus
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What does ADAR1 do?
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it causes adenosine to mutate to inosine, which now looks ilke guanosine--it is for RNA
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Which virus is ADAR1 for?
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measles, polyoma, parainfluenza, ALV
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What is Irf?
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It sustains IFN tarnscription and induction, signal transduction
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What is NO synthetase?
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Produces NO that inhibits replication
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Which viruses is NO synthetase for?
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pox, herpes
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Which viruses is Mx for?
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hanta/buny and influenza
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Which step does Mx prevent of bunyavirus?
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prevents nucleocapsid from entering Golgi
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Which step does Mx prevent of influneza?
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prevents nucleocapsid from entering nucleus
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Which viruses prevent IFN synthesis?
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EBV, influenza, vaccinia
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Which viruses prevent IFN synthesis? EBV
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BCRF-1
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Which viruses prevent IFN synthesis? influenza
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NS1
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Which viruses prevent IFN synthesis? vaccinia
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A18R
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Which virus inhibit Rnase L?
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SV40
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Which virus inhibits MxA?
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hepB capsid
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which are IL-10 virokines?
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EBV, vaccinia, KSHV
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which are IL-10 virokines? EBV
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BCRF-1
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which are IL-10 virokines? vaccinia
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VGF
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which are IL-10 virokines? KSHV
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MIP
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Which are vireceptors?
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Vaccinia, Myxoma
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Which are vireceptors? vaccinia
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B18R (IFN-alpha)
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Which are vireceptors? myxoma
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M-T1
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Which steps can Pkr be inhibited at?
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viral dsRNA mop up, mop up inactive Pkr and prevent its activation, prevent phosphorylation, binds phosphatase to Elf2alpha, pseudosubstrate
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Which viruses bind to dsRNA?
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reovirus, vaccinia, influenza, HSV
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Which viruses bind to dsRNA? reovirus
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sigma3
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Which viruses bind to dsRNA? vaccinia
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E3L
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Which viruses bind to dsRNA? influenza
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NS1
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Which viruses bind to dsRNA? HSV
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US11
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Which viruses bind to inactive Pkr?
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adenovirus, HIV, EBV
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Which viruses bind to inactive Pkr? -adenovirus
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VA RNA
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Which viruses bind to inactive Pkr? HIV
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TAR RNA
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Which viruses bind to inactive Pkr? EBV
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EBER
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Which virus (1) prevent dimerization of pkr?
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Hep C
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Which virus (1) prevent dimerization of pkr? hep C
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PK2
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Which virus (1) binds ot phsphtase that dephosphorylates Elf2 alpha?
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HSV
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Which virus (1) binds ot phsphtase that dephosphorylates Elf2 alpha? HSV
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ICP34.5
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Which virus (3) is psuedosubstrate for Pkr?
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HepC, HIV, Vaccinia
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Which virus (3) is psuedosubstrate for Pkr? HepC
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E2
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Which virus (3) is psuedosubstrate for Pkr? HIV
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Tat
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Which virus (3) is psuedosubstrate for Pkr? vaccinia
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K3L
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What is a psuedosubstrate?
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binds to active Pkr and prevent sdimer formation
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What is TRIM5 alpha?
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blocks simina HIV from uncoating, i.e. blocks capsid
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What does APOBEC 3G do?
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cytosine deaminase to uracil, for DNA
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Which virus protein counters APOBEC
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vif
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what is a permissive cell? (3 types)
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HeLa, 293, COS7
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What is not in a permissive cell?
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APO BEC 3G
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Which viruses does APOBEC3G helop with ?
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equine infectious anemia, MLV, hep B
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Which T helper cell does IL-2 and IL-12 activate?
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Th1
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Which T helper cell does IL-4 activate?
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Th2
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Which T helper cell does IL-10 activate?
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Th2
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Which T helper cell does IL-5, 6, activate?
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Th2
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Which T cell does IFN gamma help activate?
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CD8
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Which are the CTL? CD4 or CD8
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CD8
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What are in granules that CTL release?
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granzymes, perforin
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Is granzymes only thing that induces apoptosis?
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no, also Fas lgiand on CTL
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What do antibodies do?
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prevent virus bindint to cell, complement, aggregation of pathogens, enhance opsonization/phagocytosis
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Which MHC is for extracellular peptides?
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MHC II
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Which MHC is for intracellular peptides?
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MHC I
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Which MHC involves Tap1-2?
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MHC I
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Where does Tap-1-2 take MHC?
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to ER lumen
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which is coreceptor for MHC I cells after they go from Golgi?
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CD8
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Which MHC involved with endocytosis?
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MHC II
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What are 5 ways to evade adaptive immune defense?
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Ag shift/drift, interfere w/ MHC, latent infection, apoptosis of CD8 and CD4, direct infection/destruct of immune sys
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Which viruses involved in shift/drift?
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rhino, HIV, influenza
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Which viruses involved in killing CD8 and CD4 cells by apoptosis? i.e. exp Fas ligand
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HIV, HTLV, hCMV
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Which viruses involved in killing CD8 and CD4 cells by apoptosis? i.e. exp Fas ligand -HIV
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Nef, Tat, SU
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Which viruses involved in killing CD8 and CD4 cells by apoptosis? i.e. exp Fas ligand -HTLV
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tax
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Which viruses interfere w/ MHC I?
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EBV, HSV, HIV, hCMV, adenovirus,
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Which viruses interfere w/ MHC I? -EBV
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EBNA1 -interfere w/ proteasome degradation
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Which viruses interfere w/ MHC I? -HSV
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ICP47 -blocks TAP1/TAP2
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Which viruses interfere w/ MHC II?
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HIV, HSV, EBV
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Which viruses interfere w/ MHC II? -HIV
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Nef, inhibit pH drop in late endosome
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Which viruses interfere w/ MHC II? -EBV
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BZLF2-binds to MHCII, prevent expression on surface
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Which viruses interfere w/ MHC II? -HSV KOS strain
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removes MHC II from fusion vesicle
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Which viruses interfere w/ MHC I? -HIV which proteins
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TAt, Nef
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Which viruses interfere w/ MHC I? -HIV Tat
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MHC I gene transcription
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Which viruses interfere w/ MHC I? -HIV Nef
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internalization MHC I from cel surface, transport form golgi to lysosome
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Which viruses interfere w/ MHC II? -HIV Nef
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acidification of lysosomes affecting loading of peptides, down modulate surface exp
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How does HIV destruct immune cells? which proteins
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env, nef, vpu disrupt CD4, and env disrupts CCR5, high levels IgG to destruct B cells, destruct CD8, cytokines, chemokines
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