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122 Cards in this Set

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block host cell inducing apoptosis -which viruses
adenovirus, EBV, HepB, CMV, Marek's
block host cell inducing apoptosis adenovirus
E1B/E4
p53
block host cell inducing apoptosis EBV
BZLF1, BALF1
in this order, p53, caspase9
block host cell inducing apoptosis HepB
pX
p53
CD8 -MHC what type
MHC type I
CD4-MHC what type
MHC type II
helper cell to induce humoral, which type
CD4 Th2
hel[per cell to induce cytotixc which type
CD4 Th1
inhibit STAT-which viruses
HSV, sendai, protein V, adenovirus E1A
inhibit STAT-adenovrius
E1A
inhibit JAK-which viruses
polyoma, CMV
inhibit JAK-polyoma
large T
inhibit RNaseL -which virus
SV40
inhibit MxA-which virus
HepB
inhibit MxA-HepB
capsid
CAIV-master strain
H2N2
CAIV-type of vaccine
live attenuated
CAIV-current strain
H3N2, H1N1
polio Sabin-type of vaccine
live attenuated
mumps-type of vaccine
live attenuated
rubella-type of vaccine
live attenuated
varicella-type of vaccine`
live attenuated
yellow fever-type of vaccine
live attenuated
Trim 5 alpha-which virus
HIV-1
trim 5 alpha-what does it do
binds HIV-1 capsid in monkeys
trim 5 alpha-human?
no idea
trim 1
blocks MLV
trim 19
blocks foamy tas replication (retrovirus)
trim 22
downregulate HIV-1 transcription
which trim induced by interferon
trim 22
activates anti-apoptotic genes-which viruses
CMV, Marek's
blocks caspase 9
EBV BALF1
complement--innate/adaptive
innate
professional presenting Ag cells
macrophages, B cells, dendrites
which 2 types of cells are IFN gamma?
T cells, NK cells
What activates interferon exp?
dsRNA
Do IFNs activate MHC I, II, which one or both?
both
What is the end result of interferon activation?
syn of antivrial proteins
What are regulatory IFN proteins?
IFN3, IFN7
Which host cell protein is activated by dsRNA?
PKR
What are the proteins activated by IFN? (Main Pro)
Mx, ADAR1, Irf, NO synthase , PKR, RNase L, 2'5 oligo A synthetase,
What does Pkr do?
Ser phosphorylates/locks elf-2alpha in complex with elf-2B and GDP, so it can't activate 40S ribosome, translation initiation
what does RNase L and 2'5 oligo A syntheaste do?
they oligomerize adenlyic acid and activate Rnase L, which inhibits all cellular and viral RNA
What does Mx do?
Mx inhibits nucleocapsid proteins from going into the Golgi or nucleus
What does ADAR1 do?
it causes adenosine to mutate to inosine, which now looks ilke guanosine--it is for RNA
Which virus is ADAR1 for?
measles, polyoma, parainfluenza, ALV
What is Irf?
It sustains IFN tarnscription and induction, signal transduction
What is NO synthetase?
Produces NO that inhibits replication
Which viruses is NO synthetase for?
pox, herpes
Which viruses is Mx for?
hanta/buny and influenza
Which step does Mx prevent of bunyavirus?
prevents nucleocapsid from entering Golgi
Which step does Mx prevent of influneza?
prevents nucleocapsid from entering nucleus
Which viruses prevent IFN synthesis?
EBV, influenza, vaccinia
Which viruses prevent IFN synthesis? EBV
BCRF-1
Which viruses prevent IFN synthesis? influenza
NS1
Which viruses prevent IFN synthesis? vaccinia
A18R
Which virus inhibit Rnase L?
SV40
Which virus inhibits MxA?
hepB capsid
which are IL-10 virokines?
EBV, vaccinia, KSHV
which are IL-10 virokines? EBV
BCRF-1
which are IL-10 virokines? vaccinia
VGF
which are IL-10 virokines? KSHV
MIP
Which are vireceptors?
Vaccinia, Myxoma
Which are vireceptors? vaccinia
B18R (IFN-alpha)
Which are vireceptors? myxoma
M-T1
Which steps can Pkr be inhibited at?
viral dsRNA mop up, mop up inactive Pkr and prevent its activation, prevent phosphorylation, binds phosphatase to Elf2alpha, pseudosubstrate
Which viruses bind to dsRNA?
reovirus, vaccinia, influenza, HSV
Which viruses bind to dsRNA? reovirus
sigma3
Which viruses bind to dsRNA? vaccinia
E3L
Which viruses bind to dsRNA? influenza
NS1
Which viruses bind to dsRNA? HSV
US11
Which viruses bind to inactive Pkr?
adenovirus, HIV, EBV
Which viruses bind to inactive Pkr? -adenovirus
VA RNA
Which viruses bind to inactive Pkr? HIV
TAR RNA
Which viruses bind to inactive Pkr? EBV
EBER
Which virus (1) prevent dimerization of pkr?
Hep C
Which virus (1) prevent dimerization of pkr? hep C
PK2
Which virus (1) binds ot phsphtase that dephosphorylates Elf2 alpha?
HSV
Which virus (1) binds ot phsphtase that dephosphorylates Elf2 alpha? HSV
ICP34.5
Which virus (3) is psuedosubstrate for Pkr?
HepC, HIV, Vaccinia
Which virus (3) is psuedosubstrate for Pkr? HepC
E2
Which virus (3) is psuedosubstrate for Pkr? HIV
Tat
Which virus (3) is psuedosubstrate for Pkr? vaccinia
K3L
What is a psuedosubstrate?
binds to active Pkr and prevent sdimer formation
What is TRIM5 alpha?
blocks simina HIV from uncoating, i.e. blocks capsid
What does APOBEC 3G do?
cytosine deaminase to uracil, for DNA
Which virus protein counters APOBEC
vif
what is a permissive cell? (3 types)
HeLa, 293, COS7
What is not in a permissive cell?
APO BEC 3G
Which viruses does APOBEC3G helop with ?
equine infectious anemia, MLV, hep B
Which T helper cell does IL-2 and IL-12 activate?
Th1
Which T helper cell does IL-4 activate?
Th2
Which T helper cell does IL-10 activate?
Th2
Which T helper cell does IL-5, 6, activate?
Th2
Which T cell does IFN gamma help activate?
CD8
Which are the CTL? CD4 or CD8
CD8
What are in granules that CTL release?
granzymes, perforin
Is granzymes only thing that induces apoptosis?
no, also Fas lgiand on CTL
What do antibodies do?
prevent virus bindint to cell, complement, aggregation of pathogens, enhance opsonization/phagocytosis
Which MHC is for extracellular peptides?
MHC II
Which MHC is for intracellular peptides?
MHC I
Which MHC involves Tap1-2?
MHC I
Where does Tap-1-2 take MHC?
to ER lumen
which is coreceptor for MHC I cells after they go from Golgi?
CD8
Which MHC involved with endocytosis?
MHC II
What are 5 ways to evade adaptive immune defense?
Ag shift/drift, interfere w/ MHC, latent infection, apoptosis of CD8 and CD4, direct infection/destruct of immune sys
Which viruses involved in shift/drift?
rhino, HIV, influenza
Which viruses involved in killing CD8 and CD4 cells by apoptosis? i.e. exp Fas ligand
HIV, HTLV, hCMV
Which viruses involved in killing CD8 and CD4 cells by apoptosis? i.e. exp Fas ligand -HIV
Nef, Tat, SU
Which viruses involved in killing CD8 and CD4 cells by apoptosis? i.e. exp Fas ligand -HTLV
tax
Which viruses interfere w/ MHC I?
EBV, HSV, HIV, hCMV, adenovirus,
Which viruses interfere w/ MHC I? -EBV
EBNA1 -interfere w/ proteasome degradation
Which viruses interfere w/ MHC I? -HSV
ICP47 -blocks TAP1/TAP2
Which viruses interfere w/ MHC II?
HIV, HSV, EBV
Which viruses interfere w/ MHC II? -HIV
Nef, inhibit pH drop in late endosome
Which viruses interfere w/ MHC II? -EBV
BZLF2-binds to MHCII, prevent expression on surface
Which viruses interfere w/ MHC II? -HSV KOS strain
removes MHC II from fusion vesicle
Which viruses interfere w/ MHC I? -HIV which proteins
TAt, Nef
Which viruses interfere w/ MHC I? -HIV Tat
MHC I gene transcription
Which viruses interfere w/ MHC I? -HIV Nef
internalization MHC I from cel surface, transport form golgi to lysosome
Which viruses interfere w/ MHC II? -HIV Nef
acidification of lysosomes affecting loading of peptides, down modulate surface exp
How does HIV destruct immune cells? which proteins
env, nef, vpu disrupt CD4, and env disrupts CCR5, high levels IgG to destruct B cells, destruct CD8, cytokines, chemokines