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17 Cards in this Set
- Front
- Back
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Receptor tyrosine kinase (activity)
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Have intrinsic enzymatic activity
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Kinase (function, specifity)
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Attaches ATP P to amino acids
Must attach to S, Y, T Needs to have an OH group |
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Receptor Kinase (structure)
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One helix passes through membrane
Turn into dimers, once ligand is bond C terminus is on inside |
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Receptor kinase (mechanism)
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Autophosphorylates
Causes other proteins to bind and they become phosphorylated |
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SH2 domain
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Binds to phosphorylated Y
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PTB domain
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Binds to phosphorylated Y
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PH domain
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Binds to membrane
Binds to phosphoinositides |
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Grb2
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Has 2 SH3 and 1 SH2
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SH3 domain
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Binds to proline residues
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Shc
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Has PTB (for tyrosine) and SH2
Has phosphorylated area |
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MAP kinase (function)
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Induces cell growth
Controls gene expression |
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Ras (function)
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Connects MAP to tyrosine kinases
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ras (mechanism)
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Activated by SOS
ras activates raf |
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SOS (structure, function)
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Has polyproline area
Binds to SH3 of Grb2 Localized to membrane (since Grb2 binds to RTK) |
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Anthrax (pathogenesis)
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Breaks up the scaffolding that holds MEKs and MAPKs together
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DAG (function)
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Activates protein kinase c
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IP3 (function)
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Releases Ca stores
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