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7 Cards in this Set
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metoprolol
name class dose |
Lopressor
Toprol-XL Beta blocker, B1 selective 25-400 mg, max 400mg/day |
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metoprolol
MOA |
Beta blocker, B1 selective
dose <100 mg do not effect B2 recpetors |
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metoprolol
indications |
HTN [25-400 mg PO qd]
angina [100-400 mg PO qd] CHF [12.5-200 mg PO qd] |
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metoprolol
black box |
Avoid Abrupt Cessationsevere angina exacerbation, MI, and ventricular arrhythmias in angina pts after abrupt D/C; taper gradually over 1-2wk and monitor when D/C chronic tx, especially in ischemic heart dz; restart tx even temporarily if angina worsens or acute coronary insufficiency develops; warn pts to avoid tx interruption or D/C w/out MD advice; avoid abrupt D/C in all pts in case of unrecognized CAD
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metoprolol
contraindications/cautions |
contraindicated in severe bradycardia, second or third degree heart block, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless a permanent pacemaker is in place), and in patients who are hypersensitive to any component of this product.
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metoprolol
drug interactions |
central alpha 2 agonists- increased risk of withdrawl HTN
cimetidine- increased risk of bradycardia, hyptension (use a non hepatically cleared BB atenolol, nadolol) COX 2 inhibitor- sodium/water retention fenoldopam- risk of hypotension fibric acid- exacerbate hypertriglyceridemia NSAIDs- decrease antihypertensive insulin- hypoglycemia, mask symptoms saquinavir- risk of PR prolongation, arrhythmias |
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metoprolol
serious AEs common AEs |
CHF, heart block, cardiogenic shock, bradycardia, raynauds, gangrene, bronchospasm, hepatitis, hypersensitivity rxn, photosensitivty, lupus erythematosus, agranulocytosis
fatigue, dizziness, diarrhea, pruritus, rash, depression, dyspnea, bradycardia |
