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9 Cards in this Set
- Front
- Back
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This step of metabolism makes a drug more hydrophilic and hence augments elimination
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Phase I
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Different steps of Phase I
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Oxidation
Reduction Hydrolysis |
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Inducers of Cytochrome P450 (CYP450)
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Barbiturates
Phenytoin Carbamazepine Rifampin |
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Inhibitors of CYP450
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Isoniazid
Cimetidine Ketoconazole Erythromycin Grapefruit |
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Products of Phase II conjugation
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Glucuronate
Acetic Acid Glutathione Sulfate |
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Type of kinetics when a constant percentage of substrate is metabolized per unit time
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First order kinetics
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Drug elimination with a constant amount metabolized regardless of drug concentration
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Zero order kinetics
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Target plasma concentration times (volume of distribution divided by bioavailability)
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Loading dose (Cp*(Vd/F))
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Concentration in the plasma times (clearance divided by bioavailability)
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Maintenance dose (Cp*(CL/F))
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