Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
epidemiology of metabolic syndrome
|
24% of US adults
47 million ppl 44% of ppl over age 50 children as young as 4 |
|
|
diagnostic criteria for metabolic syndrome
|
phenotypic expression
two sets of diagnostic criteria |
|
|
two sets of diagnostic criteria
|
National cholesterol education program
International diabetes federation |
|
|
National Cholesterol Education Program
|
need 3 of 5
abdominal measurement(102cm men and 88cm in women) triglycerides greater than 150 HDL less than 40 in men and 50 in women 130/85 or greater fasting glucose 100 or higher |
|
|
International Diabetes Federation
|
Waist: 94cm in men and 80 in women AND 2 of 4
triglycerides greater than 150 HDL less than 40 in men and 50 in women 130/85 or greater fasting glucose greater than 100 |
|
|
high food intake of bad nutrients =
|
oxidative stress and inflammation
|
|
|
oxidative stress and inflammation =
|
interruption of insulin signal transduction
|
|
|
interruption of insulin signal transduction =
|
insulin resistance
|
|
|
insulin resistance =
|
atherosclerotic events and oxidative stress and inflammation
|
|
|
properties of insulin
|
lowers blood glucose
anti-inflammatory anti-oxidant anti-thrombotic anti-atherosclerotic |
|
|
obesity =
|
pro-inflammatory
TNF-a produced by adipocytes Adiponectin: anti-inflammatory that is low in obesity |
|
|
what follows obesity
|
lipid abnormalities, elevated blood pressure, elevated glucose
|
|
|
usually, insulin resistance is a result of
|
inflammation that interferes with insulin signal transduction-deadly cycle
|
|
|
atherosclerotic events
|
strokes, MI, other diseases
|
|
|
complications of metabolic syndrome
|
lipid abnormalities- not enough HDL
elevated blood pressure-oxidative stress and NO elevated blood glucose pro-inflammatory atherosclerotic disease |
|
|
treatment for metabolic syndrome
|
lifestyle risk factors
recommend smoking cessation cholesterol- LDL blood pressure glucose pro-thrombotic state pro-inflammation |
|
|
underlying causes for metabolic derangements
|
excess nutrients are pro-inflammatory AND cause weight gain
obesity = pro-inflammatory pro: inflammation, thrombotic, atherosclerotic |
