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14 Cards in this Set
- Front
- Back
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Described as an amphibolic pathway because... |
It has catabolic and anabolic functions |
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Electron carriers involved in TCA cycle? |
NAD and FAD |
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Reactive part of NAD? |
Nicotinamide ring |
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Reactive part of FAD? |
Isoalloxazine ring |
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Where does the TCA cycle take place? |
mitochondrial matrix |
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Yield from 1Acetyl CoA? |
10 ATP |
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Rate of TCA cycle corresponds to..? |
Rate of ETC |
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Which reactions regulate the TCA cycle? |
-Citrate Synthase -Isocitrate DH -aKG DH -Malate DH |
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How does the Citrate Synthase reaction regulate TCA? |
Increased [citrate]> decreased OA. Enzyme switched off, Acetyl CoA diverted |
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How does ICDH reaction regulate TCA? |
-Rate limiting step -Increased ATP + NADH switch off -Increased ADP and Ca2+ switch on |
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How does aKGDH reaction regulate TCA? |
-Succinyl CoA is a competitive inhibitor -NADH is a -ve allosteric effector -Increased GTP inhibits -Increased Ca2+ switches on - 2ndmes |
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Control of TCA cycle |
Mainly dependent on O2 availability |
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Why is fluoroacetate toxic? |
Binds to aconitase inhibits the enzyme blocks isocitrate formation |
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How does malonate block TCA cycle? |
A 3C homologue of succinate Able to bind with malate DH - competitive inhibitor Causes build up of succinate, citrate and aKG |
