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4 Cards in this Set
- Front
- Back
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Amitryptiline tricyclic antidepressant |
MOA: blocks seratonin reuptake I: second-line in moderate to severe depression, neuropathic pain CI: elderly, heart problems, constipation, epilepsy, raised IO pressure, enlarged prostate SE: dry mouth, hypotension, arrhythmias, hallucinations, mania, sexual dysfunction, withdrawal problems Interact: monoamine oxidase inhibitors O: can only be perscribed by those with additional training |
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Citalopram selective seratonine reuptake inhibitors (SSRIs) |
MOA: as described, increaces serotonin availability. less blockade then tricyclic and no noradrenaline effect. I: first line in mod-sever depression, second line in mild when phsycological things fail. OCD, panic disorder CI: epilepsy, peptic ulcer, young, liver probs SE: GI upset, appetite and weight disturbance, hypersensitivity, suicidal thoughts, prolong QT, increase bleed risk, withdrawal problems Interact: monoamine oxidase inhibitors, other QT lengthening drugs, O: oral, daily, 20mg start, take until 6 months after symptoms stop, 2 years if recurrent. reduce dose slowly over 4 weeks. |
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Diazepam (shorter acting, seizures) Benzodiasepines |
MOA: enhanced binding of GABA to type A GABBA receptors (Cl-channels), cells are depressed and resist de-polarisation. sedative effect, sleepy, less anxious. I: first line seizures and status epilepticus, alcohol withdrawal, sedation for procedures, short term for severe anxiety or insomnia CI: elderly, liver on lung problems, neuromuscular disease SE: drowsiness, sedation & coma, dependence and withdrawal reaction. Interact: eliminated by CP450 O: Diazepam is used in seizures more then the others |
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Donepezil Acetylcholinesterase inhibitors |
MOA: Inhibits hydrolysis of acetylcholine and allows for more of it at cholinergic synapses, improves cognistion in alzheimers patients but does not slow disease progression I: alzheimers CI: NA SE: GI upset, headache, faints, prolong QT Interact: NSAIDs O: |
