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8 Cards in this Set
- Front
- Back
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MEN I affects?
(Wermer's syndrome) |
parathyroid glands (75%)
anterior pituitary (50%) enteropancreatic neuroendocrine system (35%) |
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MEN IIa affects?
Sipple syndrome |
medullary thyroid carcinoma (100%)
pheo (40%) (usually B/L, occ. malignant) hyperparathyroidism (60%) (usually hyperplasia- also adenoma) |
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MEN IIb
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medullary thyroid carcinoma
pheo (usually B/L) multiple mucocutaneous neuromas, marfanoid habitus (usually by age 20) |
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MEN IIb mucosal neuroma presentation
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hypertrophied lips, thickened eyelids
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MEN- surgical treatments
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MEN I and IIa: subtotal or total parathyroidectomy with autotransplantation
total thyroidectomy for medullary thyroid CA, possible nodal dissection |
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Thyroid embryology
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develops at base of tongue between 1st pair of pharyngeal pouches, in area called foramen cecum; descends down midline to final location overlying thyroid cartilage, dev. into bilobed organ w/ ishtmus between lobes. occ. thyroglossal cyst left; pyramidal lobe in 50-80% of pop., extends superiorly from isthmus
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hypercalcemic crisis Tx:
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saline, furosemide, bisphosphonates, and antiarrythmics PRN.
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parathyroid CA s/Sx:
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40-50% present with firm, fixed mass that is palpable.
high Ca, PTH, HCG levels. Neck pain, voice change |
