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10 Cards in this Set
- Front
- Back
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MEN1 |
1. Parathyroid tumor - almost 100% by 40yo 2. Pituitary - lactotroph adenoma most common 3. Pancreatic islet cell OR gastrinoma (ZES) - in 1/3 - ZES most commonly symptomatic |
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MEN1 Genetics |
Autosomal dominant MEN1 gene |
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Definition |
2 out of 3 tumors |
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MEN2 |
2 syndromes - MEN2A 》4 Subtypes - MEN2B |
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MEN2 Genetics |
Both MEN2A + MEN2B - RET protoncogene - on Chrosome 10 Autosomal dominant |
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MEN2A |
Characterised by: 1. Medullary Thyroid Cancer - almost 100% penetrance - variable onset 2. Phaeochromocytoma 3. Primary Parathyroid Hyperplasia |
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MEN2B |
Characterised by: 1. MTC - in almost 100% 2. Phaeochromocytoma (Not 1parathyoroid hyperplasia) |
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MEN2B |
Early age of onset More aggressive |
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MEN2B |
Also includes: - mucosal neuromas (inc intestinal》GI sxs) - marfanoid habitus |
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MEN Treatment |
Surgery |
