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30 Cards in this Set
- Front
- Back
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Megaloblastic anemia can be caused by:
A.) tapeoworm infestation B.) gastric resection C.) nutritional deficiency D.) all of the above |
D.) all of the above
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Megaloblastic anemia related to folic acid deficiency is associated with:
A.) abnormal absorption B.) increased utilization C.) nutritional deficiency D.) all of the above |
D.) all of the above
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The underlying type A gastritis that causes pernicious anemia is immunologically related to:
A.) autoantibody to IF B.) low serum gastrin C.) autoantibody to parietal cells D.) both A and C |
D.) both A and C
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Cobalamin transport is mediated by:
A.) IF B.) TC II C.) R proteins D.) all of the above |
D.) all of the above
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In megaloblastic anemia, the typical erythrocytic indices are:
A.) MCV increased, MCH increased, and MCHC normal B.) MCV increased, MCH variable, and MCHC normal C.) MCV increased, MCH decreased, and MCHC normal D.) MCV normal, MCH increased, and MCHC normal |
A.) MCV increased, MCH increased, and MCHC normal
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The peripheral erythrocyte morphology in folate deficiency is similar to pernicious anemia, the RBCs are:
A.) small B.) normal size C.) large |
C.) large
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In a case of classic pernicious anemia, the patient has:
A.) leukopenia B.) hypersegmented neutrophils C.) anemia D.) all of the above |
D.) all of the above
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The reticulocyte count in a patient with untreated pernicious anemia is characteristically:
A.) 0% B.) 0.3% C.) <1.0% D.) approximately 1.8% |
C.) <1.0%
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Serum haptoglobin-binding capacity in pernicious anemia
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decreased
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Serum B12 in pernicious anemia
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decreased
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Folate in pernicious anemia
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normal
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Serum iron in pernicious anemia
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Increased
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Percent transferrin in pernicious anemia
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Increased
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Serum lactic dehydrogenase (LDH)
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significantly increased
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Unconjugated bilirubin
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Increased
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Smear of pernicious anemia
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- ovalo-macrocytes
- neutrophilic hypersegmentation |
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Hematocrit of pernicious anemia
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decreased
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Hemoglobin of pernicious anemia
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decreased
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RBC count of pernicious anemia
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decreased
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MCV of pernicious anemia
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increased, >96fL
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WBC of pernicious anemia
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decreased
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Retic count of pernicious anemia
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decreased
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Causes of megaloblastic anemia
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folic acid deficiency and vitamin B12 deficiency
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Maturation of nucleus and cytoplasm in megaloblastic anemia
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- dysynchrony in nuclear and cytoplasmic maturation
- slows nuclear replication causing a large nucleus - increased cytoplasmic RNA |
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The increase in LDH is caused by?
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when cells never undergo mitosis and breakdown in the bone marrow
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Treatment of megaloblastic anemia
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replenishment of Vit. B12 or folic acid
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Etiology of B12 Deficiency
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1.) Increased utilization because of parasites
2.) Malabsorption caused by gastric resection, gastric carcinoma, or sprue 3.) Nutritional deficiency 4.) Pernicious anemia, associated with chronic atrophic gastritis |
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Etiology of folate deficiency
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1.) Abnormal absorption caused by celiac disease or sprue
2.) Increased utilization from pregnancy 3.) Treatment with antimetabolites that antagonize folic acid |
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Cause of pernicious anemia
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an autoantibody to intrinsic factor, antibodies directed against parietal cells
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Transport of B12
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1.) Intrinsic factor
2.) Transcobalamin II 3.) R proteins |
