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9 Cards in this Set
- Front
- Back
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Learning objective |
Explain the effects of mitochondrial inheritance. Recognize patterns of mitochondrial inheritance in pedigree charts.
Explain the concept of mosaicism and provide examples of this condition. |
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Effects of mitochondrial inheritance |
From mother to her offspring |
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Why mitochondrial inheritance is from mother to her offspring |
Mitochondrial genes are in the cytoplasm of the egg. |
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Examples of mitrondrial genetic disorders |
MELAS syndrome: vomiting, seizures
Leber's disease - vision loss in young adults |
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Mosaicism
What is it? |
Mutations occurring in a somatic or germline cell that are passed on to the daughter cells during subsequent mitosis. |
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Mosaicism
If due to somatic mutation, what will happen? |
Some cells in the body will be affected, while others will not. |
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Mosaicism
If due to a germline mutation, what will happen? |
Some of gametes/offspring will be affected while others will not. |
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Mosacisim
Example |
Inactivation of one of the x chromosomes in each cell.
Paternal or maternal X inactivated randomly. |
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Mosacism
Inactivation of one of the x chromosomes in each cell
Name one disease and describe it |
Female carriers of Duchenne muscular dystrophy may show some muscle weakness. |
