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28 Cards in this Set
- Front
- Back
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losartan
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Treatment for Marfan Syn.; decreases expression of TGF-B by decreasing receptors or decreasing activators
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Beta blockers
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Treatment for Marfan Syn. Decrease cardiac signals, decrease cardiac symptoms
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Organophosphate (DFP)
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TOXIN:
Irreversibly binds to serine enzyme, decreases AChE |
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Atropine
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Treatment for DIFP/pesticide poison. Competes with ACh for receptors but sends no signal; allows body to make more AChE to break down ACh
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Pralidoxime
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Treatment for DIFP/pesticide. Reverses enzyme-poison bond, making AChE funcitonal again
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Pyridostigmine
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Treatment for Myasthenia Gravis. Reversibly inhibits AChE so that ACh can act longer, overcoming the decreased number of ACh receptors
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Apsirin
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Treatment for pain, thromboses. Suicide inactivator of COX (disallowing prostaglandin formation)
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Ibuprophen
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Treatment for pain. Reversibly binds to COX, decreasing prostaglandin production
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Invirase, Crixivan, Viracept, Norvir
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Treatment for HIV. Inhibit action of HIV protease
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Penicillin
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Antibiotic. suicide inactivator of bacterial cell wall transpeptidase
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Clavulanic Acid
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Inhibits bacterial resistance. Inactivates B-lactamase, which degrades B-lactam ring of penicillin
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Tetrodoxin (TTX)
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TOXIN:
block Na channels |
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Class I Antiarrhythmics
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Treats damaged heart cells. Block Na channels in damaged cardiac cells so they don't randomly depolarize, stopping arrhythmia
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atropine
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Blocks receptors in heart for ACh near SA node, increasing heart rate
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Beta blockers
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decrease heart rate by blocking epi and NE receptors
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Apsirin
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anticoagulant; suicide inactivator of TXA1 synthesis; inhibits platelet aggregation
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Warfarin (coumadin), dicoumarol
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Antithrombotic; competitive inhibition of Vit. K reductase, dissallowing activation of gln residues in prothrombin
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Heparin
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Anticoagulant; enhances antithrombin III
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t-PA
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Activates plasminogen to plasmin - cleaves fibrin clot into soluble peptide fragments
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Hemicholinium
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TOXIN:
blocks uptake of choline by nerve terminal; decreases ACh synthesis |
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cyanide
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TOXIN:
metabolic inhibitor - block mitochondrial function; decrease acetyl CoA sunthesis; decrease ACh |
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botulinum toxin
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TOXIN:
irreversibly binds to presynaptic terminal - internalized - prevents vesticular release of ACh |
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Colchicines
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TOXIN:
breaks orientation of microtubules - vesicles can't find way to membrane for release - no action potential |
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curare
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TOXIN:
inhibits ACh receptor binding - reversible |
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succinylcholine
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TOXIN:
irreversibly binds to ACh receptors - keep post synaptic channels open |
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a-Bungarotoxin
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TOXIN:
binds irreversibly to ACh receptor - completely blocks all interaction = to treat reaquires complete remodification of nervous sys (takes weeks) |
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edrophonium
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Used in diagnosis of myasthenia gravis. Prevents hydrolysis of ACh, enhanses marginal NMJ function
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Nerve gas
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TOXIN:
Suicide inhibitor of AChE, causing buildup of ACh |
