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17 Cards in this Set
- Front
- Back
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Name and draw the five basic steroid nuclei
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cholestane
cholane pregnane estrane androstane |
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A/B, B/C and C/D ring fusions are all cis/trans?
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TRANS
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Cardiac glycosides feature what steroid confirmation?
All of the steroids in 626 have what steroid conformation? |
cardiotonic sterid conformation
all ours have sterid hormone conformation |
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What is the precurer steroid to all other steroids and what pathway does it come from?
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cholesterol
acetate pathway |
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The pregnane nucleus is present in what progestins?
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mineralcorticoids and glucocorticoids
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What is the estrane nucleus missing?
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C19
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What enzyme catalyzes cholesterol to pregnenolone?
DRAW |
P450scc
side chain cleavage |
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What enzyme takes pregnenolone to progesterone?
DRAW |
3beta-HSD
3beta-hydroxysteroid dehydrogenase (delta 5, delta 4 isomerase) |
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What enzymes take progesterone to 11-deoxycorticosterone and 17alpha-hydroxyprogesterone?
what type of enzymes are these molecules? DRAW |
11-doxycorticosterone
P45021 and 17alpha-hydroxyprogesterone P45017alpha hydroxylases |
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What enzyme takes 11-deoxycorticosterone to corticosterone?
DRAW |
P45011beta
11beta-hydroxylase |
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What enzyme takes corticosterone to 18hydroxycorticosterone and aldosterone?
draw |
P450aldo
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DRAW the catalyzation of cholesteral to aldosterone with the names of enzymes
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slide 23
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how do you get to androstenedione and 11deoxycortisol from 17alpha hydroxyprogesterone?
DRAW |
androstenedione
P45017alpha 11-deoxycortisol P45021 |
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What enzyme takes androstenedione to testosterone?
DRAW |
17BHSD
hydroxysteroid dehydrogenase |
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how do you get from androstenedione and testosterone to estrone and estradiol?
Draw, and which to which? |
aromatase
androstenedione to estrone testosterone to estradiol |
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how do you get to testosterone to androsterone?
draw |
testosterone to dihydrotestosterone
5alpha-reductase dihydrotestosterone to androsterone 3alpha HSD |
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DRAW entire steroid pathway
cholesterol to androsterone |
GOOD LUCK...slide 29
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