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33 Cards in this Set
- Front
- Back
CHF2-O-CHF-CF3
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Desflurane - suprane
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Des bp______, similar to iso
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23c
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Des has _____ blood solubility so has a rapid onset and recovery thru the _______
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Low; BBB
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Des can be used in ______; has a low ______ which means low toxicity
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Outpatient surgery; metabolism
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(CF3)2-CH-O-CH2F
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Sevoflurane
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Sevo was used in ______ first
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Japan
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Sevo is similar to ______; has some decomposition in ______
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Des; soda lime
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Sevo has ______ metabolized
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5%
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General prop of halothanes: Possibility in multiple applications that there could be _______, so a potential for hypersensitivity.
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Antibody production
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General prop of halothanes: Kidney effects arise from _____ production
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Fluoride
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General prop of halothanes: MH from hyper metabolic rxns are probably d/t ________ rather than the agent itself
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Metabolic products
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General prop of halothanes: drug interactions is a problem with _______ - have a motentiation. Also problem with _____ and some ______.
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Tranqs, depressants; MAOI; cardiac agents
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General prop of halothanes: there is no particular part of the molecule that is ________ for the activity of the agent (pharmacophore).
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Responsible
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General prop of halothanes: interferes with stuff ______, has no particular receptor
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Going to the receptor
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Used for IV induction, can lead to resp depression
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Barbs
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Barbs are not used in a ______ sense d/t resp depression
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Prolonged
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Barbs have a _______ entrance to the CNS, so structures are _______
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Quick; hydrophobic
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Acts by reinforcing GABA effects; rapidly metabolized d/t members on 6 member ring
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Methohexital
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Methohexital - structure has a lot of _____ which lend a significant hydrophobic character - doesn't like water. D/t this it rapidly ____ into the CNS and t/o the body
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CH2 groups; penetrates
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Structure shows a lot of CH2s and CH3s, signif hydrophobicity. Effect takes place in seconds, recovery is quite rapid.
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Surital
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Widely used, ultra short acting, rapid onset. Truth serum
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Thiopental
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Structure doesn't look like a classic barb; came from research on PCP. Hallucinations are possible.
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Ketamine
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Ketamine is a _______, shows a mental detachment to procedures.
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Neuroleptic
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Ketamine blocks ____ excitatory trasmission, peak effect is in_____
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Glutamate; 1 min
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Ketamine is produced in a _______ d/t cost
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50/50 mixture
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Ketamine can be used alone for
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Short procedures (10-15")
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Ketamine has a carbon that can be _______, has isomers, mirror images. The ______ form is more potent.
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Stereospecific; S
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Ketamine is metabolized in the
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Liver
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D and L or L and S
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Isomers of Ketamine
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Has a significant departure from barb structure. Is an oil at room temp, low solubility
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Propofol
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Propofol acts like a
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GABA agent
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Propofol IV hypnosis occurs within ____ and lasts _____
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1 min; ~ 5 min
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Propofol is metabolized _______ and has few s/e
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Quickly
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