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11 Cards in this Set
- Front
- Back
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What are the two major concepts that buffer capacity depends on?
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1. Molar Concentration of conjugate acid/ conjugate base.
2. Ratio of their concentration *Directly proportional to their concentration |
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what are the physiological buffers?
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1. bicarbonate
2. phosphate 3. protein buffers |
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What is the most effective range for buffers?
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+ -1 pH unit on either side of the pKa value of the Weak Acid or Base in the Buffer.
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Out of these two buffer concentrations of the weak acid & its conjugate base, which one is the most effective?
0.2 M acetate buffer may contain: 0.1 M HOAc + 0.1 M Na+OAc- per Liter of H2O or 0.1 M HOAc + 0.1 M Na+OAc- per Liter of H2O |
0.1 M HOAc + 0.1 M Na+OAc- per Liter of H2O
Most effective concentration is the one that is equal to both concentrations. |
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What is the henderson-haseelbalck equation?
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pH = pKa + log [A-]/log[HA]
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pH=
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-log[H+]
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[H+]=
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hydrogen ion concentration
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Ka=
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dissociation constanst
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pKa =
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-log Ka
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Calculate the pKa of a week Acid if the
Ka is 1.75 x 10-5 |
-log Ka= -log [1.75 x 10^-5]
-log Ka = -[log 1.75 + log 10^-5] -log Ka = - [-4.76] pKa = -log Ka = -(-4.76) |
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What stereochemistry of drugs is going to dictate the chirality of drugs?
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Optical Isomers and Diasteroisomers
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