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34 Cards in this Set
- Front
- Back
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LEGISLATION OF CONTROLLED SUBTANCES
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HARRISON NARCOTIC ACT- 1914
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LAXITIVES WORK
BILE IS NEEDED FOR ACHOLOHYDRIA |
IN COLON
FAT SOULUBLE DRUGS ABSENSE OF HYDROCLORIC ACID INHIBIT ABSORPTION OF ACID BASED DRUGS |
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BASIC ALKALINE DRUGS ARE ABSORBED MORE RAPIDLY BY
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ALKALINE INTESTINAL MUCOSA
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TAKE TETRACYCLINE ON
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EMPTY STOMACH
DON'T TAKE WITH MILD NO CALCIUM |
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HYALURONIDASE IS AN ANZYME THAT
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BREAKS DOWN HYALURONIC ACID IN SQ TISSUE AND ALLOWS QUICKER ABSORBTION
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CENTRAL VENOUS LINES - GO INTO WHAT?
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SUPERIOR VENA CAVA OR TO RIGHT ATRUM OF HEART- CAUSE THEY ARE DILUTED SO FAST
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DRUGS HALF LIFE
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TIME NEEDED FOR DRUG TO DECREASE 50%
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VECTORS ARE WHAT?
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NEEDED FOR DISTRIBUTION OF DNA DURING GENEE THEAPY
LIKE LIPOSOME- BIODEGRADABLE LIPD DROPLETS CARRYING DNA THAT FUSE WITH CELLS also virus WILL CARRY DNA INTO CELL |
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WHAT IS FIRST PASS EFFECT?
aCCOUNT FOR THE DIFFERENCE BETWEEN ORAL AND IM ROUTES. |
REFERS TO ABSORPTION OF DRUGS THROUGH INTESTINAL TRACT AND THE DRUGS ENTRY INTO THE PORTAL CIRCULATION.
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one tablespoon
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15 ml
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2 tablesppns
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30 ml
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one tea cup
one cup |
180ml
240 ml |
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1pint
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480 ml
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milligram =mg
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1/1000 of a gram
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microgram = mcg or ug
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1/1000,000
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1 kg =
or 50 k = |
2.2lbs
110lbs |
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1 gram
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15 grains
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60 mg
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1 grain
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1 mg 00
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1/60 grains
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1 g
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1000 mg
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0.5 grain
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500 mg
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1 mg
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1000 mcg
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which is safer
High theraputic index (40) low theraputic index (20) |
high theraputdic index is safer.
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when does a drug peak
iv im |
iv: 15-20 minutes
im - one hour later |
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plateau
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it takes four or five half lives for the plama concentraion to reach a steady state or plateau level
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electrolyte disturbences
what is the # for sodium potassium |
sodium 136-135
potassium - 3.5-5.1 |
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chloride
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97-107
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bicarbonate
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24-29
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what is Akathisia
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motor restlessness
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dystonia
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acute muscle spasms of face neck face jar tough
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tardive dyskinesia
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involuntary and abnormal face arm or leg movements
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plattletts
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150,000 400,000
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Thrombocytosis
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Overproduction of plattlettes
400,00 + |
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Thrombocytopenia
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Below 100,000
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