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17 Cards in this Set
- Front
- Back
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Which autocoid produces the following: vasodilation, hyperalgesia, fever, diuresis, immunomodulation, and destabilizes lysosomes?
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PGE2
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Which autocoid produces the following: smooth muscle contraction and inhibits platelet aggregation?
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PGD2
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Which autocoid produces the following: vasodilation and inhibits platelet aggregation?
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PGI2
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What is prostacyclin?
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PGI2
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Which autocoid produces the following: vasoconstriction and platelet activation?
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TXA2
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PGE2 isomerase converts what to what?
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PGH2 to PGE2
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What determines which PGH2 products are produced?
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The tissue-specific enzyme expression
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True or false: thromboxane antagonists are a promising pharmacologic strategy, which have clinical indications.
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False
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What are three functions of COX-1 molecules?
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Protect the stomach, help platelets aggregate, and vasodilate the renal vasculature.
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What is the function of COX-2?
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Leads to formation of prostaglandins that are involved in the inflammatory response
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Why are COX-2 inhibitors bad?
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They inhibit PGI2 also, which normally functions to vasodilate and prevent platelet aggregation.
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True or false: COX-1 and COX-2 are constitutively expressed and ubiquitously expressed.
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False, only COX-1.
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What three molecules do COX-2 molecules induce?
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IL-1, IL-2, and TNF
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What five molecules inhibit the expression of COX-2?
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Glucocorticoids, IL-4, IL-10, IL-13, and NSAIDS (Only NSAIDS needed to inhibit COX-1)
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What happens to aspirin's potential if plasma esterases get to the molecule first?
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Aspirin can no longer irreversibly inhibit COX; it can only reversibly inhibit COX's function.
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What chemical group does aspirin add to the COX molecule when it irreversibly inhibits the COX molecule?
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Acetyl group: CH3COOH
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True or false: all NSAIDS (including aspirin) have anti-inflammatory, analgesic, and antipyretic effects.
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True (aspirin also has an anti-platelet aggregation effect).
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