Medical Microbiology

Front 1

Epidemiology of Enterobacteriacae
(mobile or not)

Back 1

-ubiquitous
-gram "-"
-part of normal intestinal flora
-motile

Front 2

Pathogenesis of Enterobacteriacae
(membrane)

Back 2

-LPS (endotoxin)
-capsule (antiphagocytic)
-Type III secretion system
-resistance to serum killing: resistance to complement binding
-antimicrobial plasmids resistance to antibiotics

Front 3

Echerichia coli
(include virulence factors)

Back 3

-5 strains
-UTI's
-meningitis
-sepsis
-gastroenteritis
-virulence factors--adhensins/exotoxins

Front 4

Enterobacteriacae

Back 4

falculative anaerobes
-grow radidly

Front 5

Enterobacteriacae ferment _______ but don't produce _________

Back 5

glucose, cytochrome oxidase

Front 6

w/ oxidase test what happens

Back 6

enzyme reagent turns purple on presence of cytochrome oxidase

Front 7

of the Enterobacteriacae, which ferment glucose and which don't

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DO: (E2KC) eschrichia, eterobacter, klebsiella, and citrobactor

DON'T: (S2PY) samonella, shigella, proteus, yersinia

Front 8

How do UTI's spread

Back 8

acquired from colon, descend to urethra, ascent into bladder and may migrate to kidney or prostate

Front 9

neonatal meningitis

Back 9

e. coli and group B strep cause majority of CNS infants
-75% posses K1 capsular antigen
-commonly present in gastrointesinal tract of pregnant women and newborn

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enteropathogenic

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-underdeveloped countries
-infant diarrhea
-spread from P2P (easily spread)
-bacterial attachment to intestinal cells results in loss of microvilli, followed by cell death
-small intestine

Front 11

enterotoxigenic

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-traveler's diarrhea
-infant diarrhea
-comsumption of fecally contamineated H2O
-can involve A-B enterotoixin that acts like cholera toxin
-developing countries
-small intestin

Front 12

enteroaggregative

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-traveler's/infants diarrhea
-developing countries
-chronic diarrhea and growth retardation
-bacteria adhere to intestinal protective biofilm formaton and produce toxins
-small intestine

Front 13

enterohemmorragic

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most common pathogenic e. coli strain in developed coutnries
-consumption of uncooked meat
-P2P may occur
-shiga toxin: disrupts protein synthesis
-complication: hemolytic uremic syndrom (kidney failure)
-large intesting

Front 14

enteroinvasive

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rare
-developing countries
-watery diarrhea
-e. coli enters cytoplsm of colinic epitherlium

Front 15

salmonella enteria
(gram and live how)

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gram "-"
not part of normal flora
endotoxin (LPS)
faculative anaerobic rod

Front 16

faculltative anaerobic rods

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-listeria monocytogens
-samonella enterica
-enterobacteria: e. coli

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strict aerobe

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nocardia

Front 18

types of s. enterica

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typi (typoid fever)
paratyphi (paratyphoid fever)
cholerasuis
typhimurium
enteritidis

Front 19

how do one attract e. enterica

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contaminated food or from direct fecal oral spread

Front 20

T OR F: SAMONELLA ENTERICA, SEROVAR ARE RARE IN US

Back 20

T

Front 21

GASTROENTERITIS

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NAUSAE, VOMITING, NON BLOODY DIARRHEA
-MOST COMMON SALMONELLOSIS IN US

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cause disease by invading and replicating in cells lining colon: subspecies of e. coli

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shigella

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shigelllosis resvoir

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humans

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shigellosis seen commonly in?

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homosexuals and households in contact w/ infected children

Front 25

Sgigellosis is accquired from

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P2P, fecal oral transmissioin, contaminated hands,

Front 26

shigella is associated w/ which type of enterobactericea

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ENTEROHEMMORRAGIC

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YERSINIA and types and how do it resist paagocytosis

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don't ferment
-Y. pestis, Y. enterocoliica, and Y. pseudotuberculosis
-resister phagocytosis by injectint bacterical progeins in phagocytes using type III secrecretion

Front 28

of the Yersinia, which causes plague

Back 28

Y. pestis

Front 29

of the Yercinia, wheich are primarily enteric

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y. enterocolitica, and Y. pseudotuberculosis

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type III secretion

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Yersinia, and enterobactaricea

Front 31

epidemiology of Y. pestis

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Urban plague: rats
Sylvatic plague: squirrels, rabbits, fields rats, and domestic cats

Front 32

epidemiology Y. enterocolitica

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pig, rodents, livesstock and rabbits

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epidemiology y. spdudoturberculosis

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rodents, wild animals and game birds

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treatment of yesterica

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streptomycin, tetercyclines, chloramhenicol, or trimpthoprim

Front 35

other enterobacteriacae

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-k. pneumoniae and oxytocoa
-proteus mirabilis
-enterobactor, citrobactor, organella, seratia

Front 36

of the other enterbacteriacase which: capsule-producin bactericia and axquired in and outsid of hospital

Back 36

k. pneumoniae and oxytocoa

Front 37

of the other enterbacteriacase which common cause of UTSs; secretes urease that cause urinary pH increase ------> Mg2+ and Ca2+ precipitate out of colution------>renal kideny stones

Back 37

proteus mirabilis

Front 38

of the other enterbacteriacase which only cause infection in immunocomproises patients and infants

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enterobactor, citrobactor, organella, seratia

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is enterobactericase hard to cultuere

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its easy to culture (stool, blook, urine, sputuem)
selective and diffenttial media, serological indetification, biochemical indification

Front 40

how to treat enterobactericea

Back 40

treatment of symptoms but no antibotics for EHEC and selmonelly gasttroenteritis.