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31 Cards in this Set
- Front
- Back
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what are the major T cell functions?
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Helper function, regulatory function and cytotoxic function
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T-cell progenitors develop in the _____________ and migrate to the ___________
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bone marrow; thymus
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Mature T-cells migrate from the ___________ to the ___________
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thymus; peripheral lymphoid organs
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Activated T-cells migrate from __________ to _____________
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lymphoid organs; sites of infection
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what are the phenotypes for helper/regulator subsets?
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CD3+/CD4+
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what are the phenotypes for cytotoxic T-cell subsets?
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CD3+/CD8+
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CD8 T cells = peptide + _________
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MHC class I (cytotoxic)
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CD4 T cells = peptide + ___________
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MHC class II
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T____ cells activate macrophages
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H1
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T______ cells activate antigen specific B cells
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H1 and H2
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60-90% of lymphocytes are __________
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T cells
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What is the purpose of flow cytometry?
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to analyze thousands of cells and determine the proteins being expressed on their surfaces
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CD4 T-cells are distinguished by the ____________ they produce
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cytokines
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TH17 cells generally function to facilitate __________
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inflammation
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T____ cells are generally functioning to prevent overresponse of the immune system
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reg
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TH____ generally produces cytokines IL-2 and IFN-gamma
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1
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TH____ generally produces IL-4, IL-5, IL-6 and IL-10
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2
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IFN-gamma is one of the most potent cytokines for activating ___________
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macrophages
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IL-4 influences isotype switch in B cells to make Ig__ antibody
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E
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TH1 cytokines ________ the reactions of TH2 cells, and vice versa
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inhibit
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T___ cells have CD25+ surface and produce IL-10 and TGF-beta, both of which are _________ cytokines
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reg; inhibitory
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TH____ cells produce IL-17, are pro-inflammatory and recruit neutrophils
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17
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___ and ____ are the main proteins of the TCR
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alpha; beta
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A small percentage of TCRs have ___ and ___ proteins
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gamma; delta
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_______ is the substantial cytoplasmic signaling component associated with TCRs
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CD3 complex
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Proper activation of T-cells requires co-stimulatory signaling along with signaling through antigen receptor (true/false)
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true
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_______ selection is the process by which self-reactive t-cells are removed in order to prevent autoimmune disease
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negative
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AIRE is a dendritic cell used in the ___________ selection process occurring in the thymus
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negative
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Maturation of T-cells occurs in the thymus ________
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medulla
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CD8 T-cells recognize a specific peptide within the _____________ molecule
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MHC Class I
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TH2 helper cells influence B cells to become _______ cells and make _________
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plasma; antibodies
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