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40 Cards in this Set
- Front
- Back
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What cells express IL-2 (T cell growth factor)?
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T cells, thymocytes, NK
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What cells express IL-4?
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TH2, Mast cells
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What cells express IL-5?
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TH2
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What cells express IL-6?
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Th2, macs
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What cells express IL-10?
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Th2, Treg, macs
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What cells express IL-12?
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Th1, dendritic cells, macs
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What cells express IL-13?
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Th2, basophils
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What cells express IL-17?
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Th17
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What cells express Type I Interferon (alpha/beta)?
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many cell types
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What cells express Type II Interferon (gamma)?
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Th1, NK
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What cells express TNF-alpha?
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macs, t cells, NKs
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What cells express TGF-beta?
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Treg, macs
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What cells express G-CSF (Granulocyte colony stimulating factor)?
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macs, endo, BM stromal cells
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What cells express GM-CSF (Granulocyte-monocyte colony stimulating factor)?
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macs, endo, T cells
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What is the function of IL-2 (T cell growth factor)?
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T, B, and NK cell prolif./act.
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What is the function of IL-4?
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Isotype switch to IgE
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What is the function of IL-5?
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Eosiniphil recruitment and activation; induces isotype switch to IgA
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What is the function of IL-6?
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Induces acute phase proteins from liver; plasma cell prolif.
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What is the function of IL-7?
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Survival and expansion of lymphoid progenitors; survival of naive and memory T cells
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What is the function of IL-8 (CXCL8)?
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chemokine for neutrophil recruitment
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What is the function of IL-10?
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Inhibits macs and DCs
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What is the function of IL-12?
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Stimulates IFN-gamma from cells; production of Th1 cells
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What is the function of IL-13?
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Anti-parasite; Isotype switch to IgE
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What is the function of IL-18/IL-1beta?
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Pro-inflammatory; enhances T and NK cell maturation, cytokine production and cytotoxicity
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What is the function of Type I Interferon (alpha/beta)?
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Anti-viral effects
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What is the function of Type II Interferon (gamma)?
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Macrophage act.; production of Th1; increased MHC expression
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What is the function of TNF-alpha?
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Pro-inflammatory; activates endo; induces cytokines
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What is the function of Chemokines?
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direct movement of cells
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What is the function of TGF-beta?
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Inhibits proliferation and act. of lymphocytes; inhibits mac act.; promotes isotype switch to IgA
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What is the function of G-CSF (Granulocyte colony stimulating factor)?
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differentiation and growth of granulocytes
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What is the function of GM-CSF (Granulocyte-monocyte colony stimulating factor)?
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Differentiation and growth of granulocyte and monocyte progenitors; act. of macs; dev. of osteoclasts
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MIF is produced by what cells?
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T cells
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What is the function of MIF
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inhibits mac migration and stimulates mac activation
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FasL is produced by what cells?
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T cells
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What is the function of FasL?
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induces apoptosis (membrane associated cytokine)
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CD40L is produced by what cells?
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T-cells
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What is the function of CD40L?
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facilitates T-cell interaction with other APC's (membrane associated cytokine)
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What cells produce IL-3?
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T cells
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What is the major effect of IL-3?
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growth of early hematopoetic progenitor cells
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What is the function of IL-17?
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Induce inflammatory cytokines and recruit neutrophils
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