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5 Cards in this Set
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Sickle Cell
Caused by what? |
*Autosomal recessive disorder =
abnormal hemoglobin leads to chronic hemolytic anemia *Rate of sickling influenced by concentration of HgB S and presence of other HgB within the cell |
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Sickle Cell
Signs and Symptoms |
*Onset first year of life when HgB F falls
*Acute painful episodes = acute vaso-occlusion from clusters of sickled RBC’s |
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Sickle Cell
Classic Lab findings |
*HCT 20-30%
*Irreversible sickled cells on smear *Reticulocytosis *Nucleated RBC’s |
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Sickle Cell
Complications |
Repeated episodes affect:
heart lungs liver Ischemic necrosis of bone Hepatomegaly Death from organ failure |
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Sickle Cell
Typical Tx |
*No specific tx
*PO Folic acid *Transfusions *Acute episode: Infection tx’d, Fluids, and oxygen given |
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