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5 Cards in this Set
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Aplastic Anemia
Causes |
bone marrow failure due to injury or abnormal stem Cell production
*Radiation *Chemotherapy *Toxins *Pharmacological agents *Sometimes SLE *Pregnancy |
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Aplastic Anemia
Signs & Symptoms |
*Fatigue
*Neutropenia = increased bacterial infections *Thrombocytopenia = mucosal and skin bleeding *Pallor *Purpura *Petechiae |
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Aplastic Anemia
Classic Lab findings |
*Hallmark is pancytopenia
*Decreased reticulocytes May have macrocytosis *Decreased neutrophils and platelets = no immature forms Bone marrow will appear hypocellular |
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Aplastic Anemia
Complications |
*Maybe confused with Leukemia or
Hypocellular Myelodysplasia *Death if severe and untreated |
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Aplastic Anemia
Typical Tx |
*RBC and platelet transfusions prn
*Infections treated with abx *Allogenic bone marrow transplant |
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