Medchem-Test Ii- Lester-Mischer

Front 1

Most recent NNRTIs? Name others in this class

Back 1

ETARARINE

Efarivenz
Neviapine
Etravirine

Front 2

First HIV Integrase inhibitor

Back 2

Raltegravir

Front 3

This drus is Active in clinical trials against HIV strains resistant to other antiretroviral drugs when included in combination therapy. It it inhibits introduction of viral DNA into host genome by blocking actions of HIV Integrase enzyme.

Back 3

Raltegravir

Front 4

An HIV enzyme crucial for post-translational modification of immature core porteins into structural proteins. Much more effective than reverse transcriptase inhibitors

Back 4

HIV Protease

Front 5

These antiretrovirals are transition state directed and their absolute configuration is vital to their action

Back 5

Protease inhibitors

Front 6

Combo of these two HIV Protease inhibitors useful for treatment of aids.

Back 6

Ritonavir
Lopinavir

Front 7

Nelfinavir, Indinavir, and Saquinavir are all...

Back 7

Protease inhibitors

Front 8

This Viral Protease inhibitor is taken by mouth daily. Along with the other protease inhibitors, it is not curative and has many SEs.

Back 8

Atazanavir

Front 9

This protease inhibitor is taken along with Ritonavir in order to achieve adequate blood levels

Back 9

Darunavir

Front 10

A Three combo drug therapy for AIDS

Back 10

Zidovudine, foscarnet, didanosine

Front 11

A three drug combo used for influenza B

Back 11

Amantadine, RIbavirin, tiazofurin

Front 12

Atripla is a successful combo of these three drugs

Back 12

Tenofovir(NRTI inhibitor)
Emtricitabine(NRTI inhibitor)
Efavirins(NNRTI inhibitor)

Front 13

Three chronic forms of hepatitis, what are the letters?

Back 13

B, D, and E

Front 14

These two forms of hepatitis mainly caused by ingestion of water or food comtaminated with fecal material.

Back 14

B and E

Front 15

Mainly spread by contact with infected blood and is poorly treated w/ existing drugs. Which Hepatitis?

Back 15

C

Front 16

How does one contract Hepatitis D?

Back 16

Contracted by Hep B sufferers who come in contact with infected blood.

Front 17

SIgns and symptoms of someone with Hepatitis

Back 17

Jaundice, Abdominal pain, Loss of Appetite, NVD, Low grade fever, HA. However some do not have symptoms

Front 18

Approved recently for treatment of chronic Hep B infections. Nucleoside-based inhibitor of reverse transcriptase. Care must be taken to avoid drug-related liver damage and lactic acidosis

Back 18

Entecavir

Front 19

For Hep B, Reported to be more active than Entecavir and less likely to elicit resistance.

Back 19

Telbivudine

Front 20

Prodrug against Hep B by blocking the action of Reverse transcriptase. Resistance develops against it more slowly than lamivudine(which was previously employed)

Back 20

Adefovir Dipivoxil