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19 Cards in this Set
- Front
- Back
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Catecholamines are needed for ?
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REM sleep
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Histamine may have involvement in
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wakefulness and REM sleep
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ACh was the 1st system shown to have role in ___?___ and initiation of __?___
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wakefulness and REM slepp
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Adenosine causes ? effect
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hypnotic
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the most important inhibitory neurotransmitter is ?
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GABA
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short acting barbituates
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pentobarbital and secobarbital
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intermediate acting barbituates
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amobarbital
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long acting barbituates
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barbital and phenobarbital
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acidic nature of barbituates is attributed to ?
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the Lactam-lactim tautomerism
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increasing the Carbon chain length at position 5 on a barbituate will do what to onset and duration?
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increase onset and decrease duration
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branched alkyl side chain on a barbiturate will ___?___ lipophilicity and ___?___ duration
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increase ; decrease
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branched alkyl side chains on barbiturates that aren't branched at the end of the chain will __?___ duration
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decrease
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Long acting barbiturates have ___?___ alkyl chains
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short
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barbiturates can cause tolerance to develop, dependence, or ___ respiration
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depress
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tertiary acyclic alcohols are mild hypnotics that have ___ onset and are ___ acting
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short ; quick
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benzodiazepines in low doses may produce a ___ effect
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sedative
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alcohol with benzodiazepines ____ effects
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increases
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benzodiazepines bind to a specific site on the ionophoric _____ receptor
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GABAa
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Imidazopyridines (Zolpidem) act on the ? and are metabolized by CYP3A4 followed by ?
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GABAa receptor BZ site
Aldehyde dehydrogenase |
