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7 Cards in this Set
- Front
- Back
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GABAa receptors are ?
GABAb receptors are ? |
Ligand Gated Ion Channel
GPCR's |
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BDZ1 binding site is in the __?__ and an interaction leads to _______?______
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nonanxiolytic sedatives
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BDZ2 binding sites are in the ____?___ and interaction leads to ___?___
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cortex, hippocampus, and spinal cord
nonsedative anxiolytics |
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Drug used as a benzodiazepine antidote that is a BDZ receptor binder
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flumazenil
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General metabolic route of first generation BDZ's is ?
Is the metabolite active |
N-dealkylation at N-1 to an active metabolite
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General metabolic route for first and second generation BDZ's is ?
Is the metabolite active? |
Alicylcic oxidation at C-3 to an active metabolite
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General metabolic route of second generation BDZ's ?
Is metabolite active? |
CH3 oxidation on triazole or imidazole ring to an active metabolite
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