Medchem Test 2 - Antihistamines

Front 1

histamine is synthesized from

Back 1

L-Histidine

Front 2

two ways to inhibit the action of histamin

Inhibitors of __?__ and __?__

Back 2

histamine release and released histamine

Front 3

H1 receptor are located peripherally primarily on ?

Back 3

mast cells and basophils

Front 4

Stimulation of H1 receptors in lungs leads to

Back 4

bronchospasm

Front 5

Classic H1 side effects include

Back 5

sedation, anticholinergic action, mucosal dryness, nasal congestion

Front 6

most potent group of first generation antihistamines

Have ____ half live and ____ duration

Back 6

alkylamines

Long and long

Front 7

this ethanolamine is the most potent and is longer lasting and has less side effects due to one extra carbon between N and O groups

Back 7

Clemastine

Front 8

Ethanolamines contain an __?__ in their structure that alkylamines do not

Back 8

Oxygen

Front 9

has _____ onset and _____ duration versus ethylenediamines and ethanolamines

Back 9

slower ; longer

Front 10

this class of antihistamines may have other properties such as:

Back 10

antinauseant, minor tranquilizer, motion sickness, and vascular disorder

Front 11

___?____ are derivatives of ethelenediamines and further elaboration of this new class led to a new class of antipsychotics

Back 11

tricyclic

Front 12

second generation antihistamines act primarily in the _____

Back 12

periphery

Front 13

2nd generation Piperidines include ?

Back 13

terfenadine, fexofenadine, loratidine, and desloratidine

Front 14

2nd generation piperazines include

Back 14

hydroxyzine, ceterizine, and levocetirizine