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16 Cards in this Set
- Front
- Back
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Antiepileptic drugs are ____ depressants used at dosages that don't impair consciousness
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CNS
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AEDs enhance GABA opening of __?__ channels
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chloride
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AEDs inactivate or block __?__
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sodium channels
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AEDs reduce __?__ flow through T-type __?__ channels
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calcium ; calcium
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Barbituates include phenobarbital and mephobarbital and are metabolized by ?
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CYP3A4
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hydantoins stabilize the ___?___ state of ___?___ channels
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inactivated ; sodium
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problem with injection of hydantoin AED is?
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physically and chemically incompatible with parenteral solutions especially salts of bases
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ethosuximide is the DOC for
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simple absence seizures
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Primedone is the __?__ derivative of Phenobarbital and is metabolized to 60-80% phenobarbital and __?__
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2-deoxy ; phenylethylmalonamide
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Gabapentin was designed as a gaba mimmetic and is use in adjunct against ?
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partial seizures
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pregabalin is the 3-substituted GABA analog and inhibits the release of:
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glutamate, NE, and Substance P
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pregabalin binds to ? and this enables it to inhibit neurotransmitter release
its used in adjunct to treat ? |
voltage gated Ca channels
Partial seizures |
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Carbamazepine blocks ?
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sodium channels
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Oxcarbazepine is a prodrug. The __?__ (wild hair) blocks formation of epoxide
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ketone
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lamotrigine blocks ? and appears to reduce glutaminergic excitatory transmission
Used to treat |
sodium channels
partial seizures |
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Lacosamide used for adjunctive treatment of partial seizures acts by enhancing slow inactivation of ?
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voltage gated sodium channels
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