Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
Bromocriptine
(side effects - 2) |
orthostatic hypotension
mental disturbances |
|
|
L-dopa
(side effects) early treatment (2) long term treatment (3) |
Early - N/V due to dopamine in medullary emetic center, arrhythmias (beta agonist)
Long - abnormal involuntary movement from dopamine in brain, psychiatric disturbances, orthostatic hypotension |
|
|
Ropinirole
(side effects - 1) |
irresistible urge to sleep (D2)
|
|
|
Pramipexole
(side effects - 1) |
irresistible urge to sleep (D2)
|
|
|
Ritogitine
(side effects - 2) |
irresistible urge to sleep (D2)
hallucinations with L-dopa |
|
|
Selegeline
(side effects - 3) |
vivid dreams
confusion exacerbates L-dopa side effects |
|
|
Rosagiline
(side effects - 1) |
hypertensive crisis with tyramine and other amines
|
|
|
Entacapone
(side effects - 1) |
discoloration of urine (nitrophenol)
|
|
|
Tolcapone
(side effects - 2) |
BLACK BOX - liver failure
discoloration of urine (nitrophenol) |
|
|
Amantadine
(side effects - 1) |
anticholingeric (anti-SLUDD)
|
|
|
L-dopa
(mechanism) |
direct replacement of dopamine
|
|
|
Carbidopa
(mechanism) |
irreversible inhibitor of LAAAD
(L-aromatic amino acid decarboxylase) |
|
|
Apomorphine
(mechanism) |
dopamine receptor agonist in medullary emetic center
|
|
|
Bromocriptine
(mechanism and specificity) |
dopamine receptor agonist
D2 agonist D1 partial agonist |
|
|
Pergolide
(mechanism and specificity) |
dopamine receptor agonist
D2, D1 full agonist |
|
|
Ropinirole
(mechanism and specificity) |
dopamine receptor agonist
D2 agonist |
|
|
Pramipexole
(mechanism and specificity) |
dopamine receptor agonist
D2 agonist |
|
|
Rotigotine
(mechanism and specificity) |
dopamine receptor agonist
D2 agonist > D1, D3 agonist |
|
|
Selegeline
(mechanism and specificity) |
MAO-B irreversible inhibitor
(keep dopamine around longer) |
|
|
Rosagaline
(mechanism and specificity) |
MAO-B irreversible inhibitor
(keep dopamine around longer) |
|
|
Entacapone
(mechanism and specificity) |
COMT reversible inhibitor
(keep dopamine around longer) |
|
|
Tolcapone
(mechanism and specificity) |
COMT reversible inhibitor
(keep dopamine around longer) |
|
|
Amantadine
(mechanism - 3) |
blocks NMDA receptors, which stimulates release of dopamine from storage
delays dopamine reuptake weak anticholinergic |
|
|
Which drugs come in forms other than oral tablets/capsules? (3)
|
apomorphine - injection
ritogitine - transdermal selegeline - ODT |
|
|
What is the bioavailability of pramipexole compared to ropinirole?
|
pramipexole 90%
ropinirole 55% |
