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25 Cards in this Set

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phentolamine
competetive non-selective alpha- antagonist
Phenoxybenzamine
irreversible non-selective alpha- antagonist
What drug treats Pheochromocytoma?
Phentolamine (competitive), Phenoxybenzamine (irreversible)
Prazosin
Selective alpha-1 receptor antagonist

tx- BPH/antihypertensive
Doxazoin
Selective alpha-1 receptor antagonist

tx- BPH/antihypertensive
Terazosin
Selective alpha-1 receptor antagonist

tx- BPH
Tamsulosin
Selective alpha-1a receptor


tx- BPH
Propanolol
Non-selective beta 1 & 2 antagonist


tx- arrhythmias (NO asthma), anxiety,hypertension, migraine
Metaprolol
Selective beta-1 antagonist
Pindolol
Partial Agonists
-give to pts with hyperlipidemia and bradycardia

tx- those who develop bradycardia from propanolol
Who can you NOT give Propranolol to?
Asthmatics, hyperlipidemics, diabetics
Labetalol
Mixed antagonists
alpha-1, beta-1, beta-2

tx- hypertension
Timolol
non-selective beta blocker


tx- glaucoma
adverse effects of beta-blockers?
hypotension, bradycardia, fatigue, insomnia, sexual dysfunction
What do aldosterone, renin and ADH have in common?
all increase blood pressure
Metyrosine
Blocks Tyrosine Hydorxylase
Reserpine
Blocks storage of catecholamines- crosses BBB
Cocain/ TCAs
Block reuptake of catecholamines in synaptic cleft
Guanethidine/Butilium
Prevents release of catecholamines from vessicle- VAMPS
Amphetamine, Ephedrine, Methylphenidate
stimulate the release of catecholamines
alpha- methyldopa
false-transmitters --> drugs act like NT or inhibit action potential
Where is MAO located?
Mitochondria
Where is COMT located?
cytoplasm- synapse
How do you measure NE release?
Vanillylmandelic Acid
What are the three catecholamines?
Catechol, NE, Phenylethylamine