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25 Cards in this Set
- Front
- Back
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phentolamine
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competetive non-selective alpha- antagonist
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Phenoxybenzamine
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irreversible non-selective alpha- antagonist
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What drug treats Pheochromocytoma?
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Phentolamine (competitive), Phenoxybenzamine (irreversible)
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Prazosin
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Selective alpha-1 receptor antagonist
tx- BPH/antihypertensive |
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Doxazoin
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Selective alpha-1 receptor antagonist
tx- BPH/antihypertensive |
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Terazosin
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Selective alpha-1 receptor antagonist
tx- BPH |
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Tamsulosin
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Selective alpha-1a receptor
tx- BPH |
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Propanolol
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Non-selective beta 1 & 2 antagonist
tx- arrhythmias (NO asthma), anxiety,hypertension, migraine |
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Metaprolol
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Selective beta-1 antagonist
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Pindolol
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Partial Agonists
-give to pts with hyperlipidemia and bradycardia tx- those who develop bradycardia from propanolol |
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Who can you NOT give Propranolol to?
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Asthmatics, hyperlipidemics, diabetics
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Labetalol
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Mixed antagonists
alpha-1, beta-1, beta-2 tx- hypertension |
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Timolol
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non-selective beta blocker
tx- glaucoma |
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adverse effects of beta-blockers?
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hypotension, bradycardia, fatigue, insomnia, sexual dysfunction
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What do aldosterone, renin and ADH have in common?
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all increase blood pressure
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Metyrosine
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Blocks Tyrosine Hydorxylase
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Reserpine
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Blocks storage of catecholamines- crosses BBB
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Cocain/ TCAs
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Block reuptake of catecholamines in synaptic cleft
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Guanethidine/Butilium
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Prevents release of catecholamines from vessicle- VAMPS
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Amphetamine, Ephedrine, Methylphenidate
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stimulate the release of catecholamines
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alpha- methyldopa
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false-transmitters --> drugs act like NT or inhibit action potential
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Where is MAO located?
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Mitochondria
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Where is COMT located?
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cytoplasm- synapse
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How do you measure NE release?
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Vanillylmandelic Acid
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What are the three catecholamines?
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Catechol, NE, Phenylethylamine
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