Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
Draw Risperidone
|
|
|
|
Which of the following molecules has the highest entropic energy cost upon binding to the µ opioid receptor?
1) Morphine 2) Leu-enkephalin 3) Etorphine 4) Naloxone |
Leu- enkephalin
|
|
|
The earliest model of opioid receptor was fit to the data for what type of opioids?
|
most moderately potent semisynthetic opioids
|
|
|
Which µ agonist has increased bioavailability due to the relatively low pKa of its basic amine?
|
Alfentanil
|
|
|
Draw the whole codeine/morphine metabolism
|
|
|
|
What are the catalysts of enkephalin processing?
What aa triggers the cleavage? |
water & (endo)peptidase
Arg-Arg; - enkephalin will be everything to the left of Arg-Arg - other will be Arg-Arg + everything to the right - both will be capped by NH3 & CO2 |
|
|
What feature of a compound would increase its likelihood to epimerize in water solutions?
|
an electronegative group (i.e. fluorine)
|
|
|
What compound would undergo deprotonation at a pH of ~6 with a resulting anion that may be able to interact ionically with aa's such as histidine and lysine?
|
sulfanamide
|
|
|
At what pH would Atorvastatin be expected to be most readily taken into cells?
|
pH < 4
|
|
|
Review SN1, SN2, E1, E2
|
see sheet
|
|
|
Are ergot alkaloids such as Methylsergide, LSD, and Lysergic acid considered α adrenergic?
|
no
|
