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54 Cards in this Set
- Front
- Back
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Which antipsychotic is the most sedative?
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chlorpromazine
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Which antipsychotic is best tolerated by patients < 40 years old?
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chlorpromazine
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What is chlorpromazine primarily used for?
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anti-emetic
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Which antipsychotic has the greatest chance of agranulocytosis and cholestatic jaundice?
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chlorpromazine
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Which antipsychotic causes photosensitivity?
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chlorpromazine
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Which antipsychotic causes corneal/lens pigmentary retinopathy?
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chlorpromazine
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What is the metabolite of thioridazine?
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mesoridazine
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Which antipsychotic has more EKG changes than with other phenothiazines, and are increased when given with TCAs?
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thioridazine
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Which antipsychotic causes pigmentary retinopathy?
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thioridazine
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What is the parent compound of mesoridazine?
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thioridazine
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Which antipsychotic has greater extrapyramidal effects, primarily with large doses in patients > 40 years old
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trifluoperazine
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Which antipsychotic has the highest potency?
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fluphenazine
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Which antipsychotic has alcohol group that allows formation of long chain esters for depot form?
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fluphenazine
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True or False - Fluphenazine has low risk of extrapyramidal side effects
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False - may appear in first week of therapy
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Which antipsychotic increases the QT interval?
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loxapine
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Which antipsychotic does NOT cause tardive dyskinesia?
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clozapine
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Which antipsychotic has high risk of agranulocytosis?
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clozapine
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Which antipsychotics are metabolized by 1A2 (smokers)? (2)
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clozapine, olanzapine
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Which antipsychotic is used with fluoxetine for depressive phases in bipolar disease
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olanzapine
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Is haloperidol a typical/atypical agent?
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typical
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What is the receptor selectivity for haloperidol?
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D >> alpha
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What is the other indication for haloperidol?
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Tourette's
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Which antipsychotic is related to haloperidol?
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pimozide
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True or False - Pimozide causes EKG changes
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True
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What is the last-line therapy for Tourette's
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pimozide
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What is the metabolite of risperidone?
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paliperidone
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What is the parent molecule of paliperidone?
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Risperidone
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What is the half life of paliperidone?
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23 hours
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Which metabolite is excreted unchanged?
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paliperidone
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Which antipsychotic is delivered via osmotic delivery device?
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paliperidone
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Which antipsychotics have monamine uptake activity? (2)
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ziprasidone, aripiprazole
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What receptors is aripiprazole a partial agonist at? (2)
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D2, 5HT1
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What is another use for aripiprazole?
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Bipolar disorder
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What drugs are used in Tourette's? (3)
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haloperidol, molindone, pimozide
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Chlorpromazine
(typical/atypical) |
typical
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Thioridazine
(typical/atypical) |
typical
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Mesoridazine
(typical/atypical) |
typical
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Trifluoperazine
(typical/atypical) |
typical
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Acetophenazine
(typical/atypical) |
typical
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Fluphenazine
(typical/atypical) |
typical
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Thiothixene
(typical/atypical) |
typical
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Loxapine
(typical/atypical) |
typical
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Haloperidol
(typical/atypical) |
typical
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Pimozide
(typical/atypical) |
typical
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Molindone
(typical/atypical) |
typical
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Clozapine
(typical/atypical) |
atypical
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Olanzapine
(typical/atypical) |
atypical
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Quietapine
(typical/atypical) |
atypical
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Risperidone
(typical/atypical) |
atypical
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Paliperidone
(typical/atypical) |
atypical
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Ziprasidone
(typical/atypical) |
atypical
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Aripiprazole
(typical/atypical) |
atypical
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Which antipsychotics are used as anti-emetics? (3)
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chlorpromazine, trifluoperazine, loxapine
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Which drugs are used for bipolar disorder? (2)
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olanzapine (depressive phase), aripiprazole
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