Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/14

Click to flip

14 Cards in this Set

  • Front
  • Back
PG cause...(3 things)
inflammation
fever
mild/moderate pain
how do COX inhibitors work?
they inhibit PGs to prevent the inflammation, fever, and pain these cause
adverse effects of NSAIDs? (4)
GI toxicity (lose E2 protection)
platelet function (platelet can't synthesize PGs)
inhibit uterine motility (block E2)
alter renal function (block PGe)
antipyretic (block E2, which inc. body temp)
diflunisal vs. aspirin?
dec.
antiplatelet effects
antipyretic

inc.
GI motility
what happens with high dose aspirin? (ex. RA)
uncouple oxphos - generate heat - inc. O2 consumption - hyperventilation to dec. CO2
what happens with aspirin overdose? (SE)
respiratory depression - circulatory collapse
what happens with A/B balance? (5) (when alter kidney & ventilation do not compensate for high acid levels?)
dehydration
acidosi (metabolic, respiratory)
inc. ulcer formation
uncouple oxphos, inc. heat
hepatic/renal: low dose ASA will inc. uric acid, high dose will dec. uric acid
when to avoid aspirin?
liver damage
hemophilia
Vit K deficiency (lack of clotting factors)
How to treat salicylate OD?
treat s/s as they appear:
charcoal: prevents absorption of ASA
bicarb - corrects acidosis
s/s of salicylate toxicity?
tinnitus, confusion
renal toxicity, vasomotor collapse, respiratory failure
What does APAP do and not do?
does: analgesia, anti-pyretic

NOT:
anti-inflammatory (weak)
platelet function (no blood thinning)
GI function (no ulcers)
no effect on acid/base balance
no effect on CV function
How to treat APAP overdose?
charcoal - prevent absorption of APAP
N-acetylcysteine: prevent binding of activated quinone metabolite to hepatic proteins --> hepatic necrosis!
Which has fewer side effects? ASA or APAP
Which is more likely to cause hepatotoxicity?
1. APAP

2. APAP
Which has conjugation pathways that are saturable?
APAP

glucurondiation 65%
sulfation 35%