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14 Cards in this Set
- Front
- Back
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PG cause...(3 things)
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inflammation
fever mild/moderate pain |
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how do COX inhibitors work?
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they inhibit PGs to prevent the inflammation, fever, and pain these cause
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adverse effects of NSAIDs? (4)
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GI toxicity (lose E2 protection)
platelet function (platelet can't synthesize PGs) inhibit uterine motility (block E2) alter renal function (block PGe) antipyretic (block E2, which inc. body temp) |
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diflunisal vs. aspirin?
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dec.
antiplatelet effects antipyretic inc. GI motility |
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what happens with high dose aspirin? (ex. RA)
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uncouple oxphos - generate heat - inc. O2 consumption - hyperventilation to dec. CO2
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what happens with aspirin overdose? (SE)
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respiratory depression - circulatory collapse
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what happens with A/B balance? (5) (when alter kidney & ventilation do not compensate for high acid levels?)
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dehydration
acidosi (metabolic, respiratory) inc. ulcer formation uncouple oxphos, inc. heat hepatic/renal: low dose ASA will inc. uric acid, high dose will dec. uric acid |
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when to avoid aspirin?
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liver damage
hemophilia Vit K deficiency (lack of clotting factors) |
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How to treat salicylate OD?
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treat s/s as they appear:
charcoal: prevents absorption of ASA bicarb - corrects acidosis |
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s/s of salicylate toxicity?
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tinnitus, confusion
renal toxicity, vasomotor collapse, respiratory failure |
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What does APAP do and not do?
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does: analgesia, anti-pyretic
NOT: anti-inflammatory (weak) platelet function (no blood thinning) GI function (no ulcers) no effect on acid/base balance no effect on CV function |
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How to treat APAP overdose?
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charcoal - prevent absorption of APAP
N-acetylcysteine: prevent binding of activated quinone metabolite to hepatic proteins --> hepatic necrosis! |
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Which has fewer side effects? ASA or APAP
Which is more likely to cause hepatotoxicity? |
1. APAP
2. APAP |
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Which has conjugation pathways that are saturable?
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APAP
glucurondiation 65% sulfation 35% |
