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40 Cards in this Set

  • Front
  • Back

Define Hematopoiesis

Hematopoiesis is the complex process of the formation and maturation of blood cless

Type of anemia resulting from red blood cell destruction

Hemolytic anemia

Define Anemia

Lower than normal hemoglobin and fewer than normal circulation erythrocytes. A sign of an underlying disorder

What is Hypoproliferative anemia

Defect in production of RBC's

Hypoproliferative Anemia Patho

Due to iron, V B12 or folate deficiency. Decreased erythropoietin production, cancer.

What is Hemolytic anemia

Excess destruction of RBC's

Hemolytic anemia patho

Due to altered erythropoiesis, or other causes such as hypersplenism, drug-induced or auto-immune processes, mechanical heart valve.

S/S of anemia

Fatigue, weakness, malaise, pallor, jaundice, cardiac or respiratory problems, tongue changes, nail changes, angular cheilosis, and pica.

Medical Management of anemia

Correct/control underlying cause. Transfusion. Treatment to specific type: dietary, vitamin supplement, etc.

Potential anemia problems

heart failure, angina, paresthesias, and confusion.

Anemia nursing interventions

Balance activity, exercise, and rest. Maintain adequate nutrition, pt education, monitor VS, monitor for potential complications.

Define Leukemia

Hematopoietic malignancy with unrelated proliferation of leukocytes

What increase absorption of iron

Vitamin C

Acute Myeloid Leukemia (AML)

Defect in stem cell that differentiate into all myeloid cells: monocytes, granulocytes, erythrocytes, and platelets. Most common nonlymphocytic leukemia. Peak incident at age 60.

S/S of Acute Myeloid Leukemia (AML)

fever and infection, weakness and fatigue, bleeding tendencies, pain from enlarges liver or spleen, hyperplasia of gums, bone pain

When there is low hemoglobin the heart ______

Pumps faster

Medical management of Acute Myeloid Leukemia (AML)

Chemotherapy-induction therapy, BMT or PBSCT

Chronic Myeloid Leukemia (CML)

Mutation in myeloid stem cell with uncontrolled proliferation of cells-Philadelphia chromosome. Uncommon in people under 20. Mean age 55-60. Life expectancy 3-5 years.

Three stages of Chronic Myeloid Leukemia (CML)

Chronic phase, transformational phase, blast crisis

Signs and symptoms of Chronic Myeloid Leukemia (CML)

Initially may be asymptomatic, malaise, anorexia, weight loss, confusion or SOB due to leukostasis, enlarged tender spleen, or enlarged liver.

Medical management of Chronic Myeloid Leukemia (CML)

imatinib mestylate (Gleevec) blocks signals in leukemic cells that express BCR-ABL protein; chemotherapy, BMT or PBSCT

Acute Lymphocytic Leukemia

Uncontrolled proliferation of immature cells from lymphoid stem cell. Most common in young children, boys more often than girls. 8-% 5-year event-free survival, but drops with increased age.

S/S of Acute Lymphocytic Leukemia

Leukemic cell infiltration is more common with this leukemia, with symptoms of meningeal involvement and liver, spleen, and bone marrow pain

Medical management of Acute Lymphocytic Leukemia

Chemotherapy, imatinib mestylate (if Philadelphia chromosome positive), BMT or PBSCT, monoclonal antibody therapy.

Chronic Lymphocytic Leukemia

Malignant B lymphocytes, most of which are mature, may escape apoptosis, resulting in excessive accumulation of cells. Most common form of Leukemia. Most common in older adults, effects men more often. Survival 2-14 years depending upon stage

S/S of Chronic Lymphocytic Leukemia

Lymphadenopathy, hepatomegaly, splenomegaly; in later stages anemias and thromocytopenia; autoimmune complications with RES destroying RBC's and platelets may occur, B symptoms include fever, sweats, weight loss.

Medical management of Chronic Lymphocytic Leukemia

early stage may require no treatment, chemotherapy, monoclonal antibody therapy

Potential Leukemia Problems

Infection, bleeding, renal dysfunction, tumor lysis syndrome, nutritional depletion, mucositis, depression

Leukemia nursing interventions

reduce risk for infection and bleeding. Frequent, gentle oral hygiene.

Improving Nutrition for Leukemia

Oral care before and after meals, analgesics before meals, appropriate treatment of nausea, small, frequent feedings, soft foods, low-microbial diet, nutritional supplements.

Disseminated intravascular coagulation (DIC)

A condition in which blood clots from throughout the body's small blood vessels. These blood clots can reduce or block flow through the blood vessels, which can damage the body's organs. Severity is variable; may be life-threatening.

Disseminated intravascular coagulation (DIC) triggers

Sepsis, trauma, shock, cancer, abrupto placentae, toxins, and allergic reactions

Medical management of Disseminated intravascular coagulation (DIC)

treat underlying cause, correct tissue ischemia, replace fluids and electrolytes, maintain blood pressure, replace coagulation factors, use heparin.

Potential Disseminated intravascular coagulation (DIC) complications

Renal failure, Gangrene, pulmonary embolism, hemorrhage, acute respiratory distress symdrome, stroke

Disseminated intravascular coagulation (DIC) Nursing interventions

Assessment and interventions should target potential site of organ damage. Monitor and assess carefully. Avoid trauma and prodecures which increase risk of bleeding, including activities which would increase intracranial pressure.

Hematologic System Structures

blood, bone marrow, spleen, lymph system)

Bone marrow aspiration and Biopsy

Out pt procedure, lies on back or side, gets local anesthetic agents, feels pressure, a few seconds of sharp pain during aspiration, <1 hr procedure

Post-bone marrow aspiration care

pressure dressing on site, monitor VS, monitor for bleeding, lie on aspirated side for 30-60 mins

Iron Deficiency Anemia

without transferrin (carries iron) iron cannot be out in circulatory system. Ferritin (stores iron in liver & heart) iron should not be excreted (in urine or stool).

Iron Deficiency Anemia risk factors

Inadequate dietary intake, malabsorption, GI surgery, loss of blood, premenopausal women, hemorrhage, chronic renal failure