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34 Cards in this Set
- Front
- Back
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Cyclosporine
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1. Protects against rejections from organ transplants
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Cyclosporine
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2. Does not induce bone marrow depression
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Cyclophosphamide
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3. Alkylating agent of both purine & pyrimidine bases of DNA
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Cyclophosphamide
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4. Txt CLL
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Cisplatin’s toxicities
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5. Nephro- & Ototoxicity
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Methotrexate
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6. Antimetabolite of folic acid: (-)dihydrofolate reductase
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Leucovorin Rescue
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7. Can block/reduce Methotrexate = folic acid via a reduced folate
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Bleomycin toxicities
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8. Pneumonitis & pulmonary fibrosis
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Azathiorine
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9. Used in organ transplantation = kidney allografts
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Azathiorine
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10. Allopurinol can its activity by (-) its biotransformation to xanthine oxidase
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MOPP
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11. Chemotherapy used in the txt of Hodgkin’s disease
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MOPP
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12. M = Mechlorethamine – nitrogen mustard 13. O = Oncovin (Vincristine) – prevents microtubule assembly 14. P = Procarbazine 15. P = Prednisone – glucocorticoid, inducing apoptosis
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Tamoxifen
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16. (-) estrogen receptor
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Tamoxifen
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17. Txt of breast tumors, can see associated endometrial CA
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Flutamide
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18. Antiandrogenic
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Flutamide
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19. Used w/ Leuprolide (LH-RH analog)
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Flutamide
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20. Txt prostatic CA
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Megestrol
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21. (-) progesterone receptor
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Megestrol
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22. Txt endometrial CA
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Fluoxymesterone
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23. Androgenic steroid
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Fluoxymesterone
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24. Txt mammary CA in postmenopausal women
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Methotrexate
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25. Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase
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Methotrexate
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26. Txt of ALL
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Methotrexate
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27. Txt of Psoriasis
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Brain tumor Txt
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28. Lomustine
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Brain tumor Txt
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29. Carmustine – Causes pulmonary fibrosis
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Streptozocin
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30. Attaches to b cells
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Streptozocin
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31. Txt of pancreatic insulinomas
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Cytarabine (AraC)
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32. Pyrimidine analog
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Cytarabine (AraC)
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33. DOC for AML
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Dactinomycin
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34. Used for Wilms tumor & rhabdomyosarcoma
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Etoposide
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35. Used for oat cell CA
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Paclitaxel
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36. Used for ovarian CA
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Amifostine
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37. Can ¯ nephrotoxicity due to chronic use of Cisplatin
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