Med Student Amnesia - Anti Infective

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Primaquine

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1. Malaria profylaxis

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Primaquine

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2. Used for extraerythrocytic forms Plasmodium vivax or P. ovale

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Ciporfloxacin

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3. Quinolone derivative

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Sulfonamides

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4. PABA structural analogs

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Sulfonamides

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5. Inhibit Folic acid synthesis

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Tertacyclines & anuria

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6. Should not be used in anuric pt due to production of (-) Nitrogen balance & ­d BUN levels.

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Tertacyclines exception

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7. Doxycycline is the exception

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Ceftriazone

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8. 3rd generation cephalosporin

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Ceftriazone

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9. DOC for bacterial meningitis in kids (ie… HiB)

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Ceftriazone

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10. One dose txt of gonorrhea

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Hepatic coma DOC

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11. Neomycin (aminoglycoside) – it supresses the normal flora = ¯g NH4 production = ¯g free nitrogen levels in the bloodstream.

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Clavulanic acid

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12. Irreversible (-)r of b lactamases, but ot of transpeptidase = use w/ a b lactamase sensitive penicillin

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Piperacillin

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13. Txt Pseudomonas aeruginosa & Klebsiella

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Piperacillin

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14. Broad spectrum antibiotic

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Streptomycin (aminoglycoside)

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15. Txt Mycobacterium tuberculosis

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Isoniazid

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16. Most commonly used drug for TB.

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Isoniazid

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17. Usually combined w/ Rifampin and/or Ethambutol

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Isoniazid

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18. Pre Txt w/ Pyridoxine (Vit B6) can prevent peripheral neuritis‘

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Pyrantel Pamoate

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19. Txt of Hookworm disease

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Pyrantel Pamoate

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20. Depolarizing NMJ (-)r

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Buy “AT” 30, “CELL” at 50

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21. A = Aminoglycosides

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Buy “AT” 30, “CELL” at 50

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22. T = Tetracyclines

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Buy “AT” 30, “CELL” at 50

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23. C = Chloramphenicol

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Buy “AT” 30, “CELL” at 50

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24. E = Erythromycin (macrolide)

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Buy “AT” 30, “CELL” at 50

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25. L = Clindamycin

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Buy “AT” 30, “CELL” at 50

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26. L = Lincomycin

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Cefoxitin

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27. Txt intraabdominal infections (ie… w/ Bacteroides fragilis)

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Cefoxitin

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28. Traditional txt has been Clindamycin & Gentamycin

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Chloramphenicol

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29. Broad spectrum antibiotic

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Chloramphenicol

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30. Bone marrow depression (common) – Aplastic anemia (rare)

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Chloramphenicol

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31. Gray baby syndrome (chloramphenicol cannot be conjugated)

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Chloramphenicol

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32. DOC Typhoid Fever (symptomatic Salmonella infection)

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Chloramphenicol

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33. DOC HiB meningitis in kids – especially resistant strain to ampicillin

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Nifurtimox

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34. Txt trypanosomiasis

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Metronidazole

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35. Txt Leishmaniasis & Amebiasis

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Metronidazole

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36. Good for anaerobic bacteria = Bacteroides fragilis

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Metronidazole

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37. DOC Trichomoniasis

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Metronidazole

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38. DOC Giardia lamblia

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Txt P. carinii

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39. TMP-SMX & Pentamidine

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Tetracycline

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40. Txt of Brucellosis & Cholera

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Tetracycline

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41. Txt Rocky Mountain Spotted Fever

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Tetracycline

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42. Txt spirochete infections = Lyme disease (Borrelia burgdorferi)

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TMP-SMX

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43. (-) dihydrofolate reductase activity

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Benzathine Penicillin G

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44. Long duration of action = given once every 3-4 weeks for Txt of Syphilis

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Praziquantel

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45. Txt Schistosomiasis (trematode [fluke] infections)

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Melarsoprol

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46. Txt Trypanosomiasis that has neurological symptoms

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Stibogluconate

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47. Txt Leishmaniasis

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Fluconazole

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48. Txt fungal encephalitis

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Amphotericin B

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49. Polyene antifingal

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Ketoconazole MOA

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50. (-) fungal ergosterol synthesis = disrupts membrane

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Griseofulvin MOA

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51. Accumulates in keratinized layers of the skin = used in dermatomycoses infections

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Mefloquine

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52. Anti malarial

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Mefloquine

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53. Txt Chloroquine resistant strains = P. falciparum

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Chloroquine

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54. Txt for Malaria when inside RBC

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Nifurtimox

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55. DOC Chagas disease due to Trypanosoma cruzi

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Erythromycin

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56. Used in pts allergic to penicillins

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Nystatin

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57. Topical txt of superficial mycotic infections = Candidiasis

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Acyclovir

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58. Guanine analog

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Acyclovir

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59. Txt Herpes infections

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Imipenem

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60. Used w/ Cilastatin

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Imipenem

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61. Can cause seizures

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Cefoperazone side effects

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62. Bleeding due to vit K level alterations

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Cefoperazone side effects

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63. Contraindicated in pts w/ bleeding disorders

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Vancomycin

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64. Used for MRSS (methicillin resistant Staph. Aureus)

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Vancomycin

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65. “Red neck”: due to histamine release causes facial flushing

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Meropenem

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66. used w/ Cilastatin

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Meropenem

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67. Does not cause seizures (cf w/ Imipenem)

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Nafcillin

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68. Only penicillin that does not need dose adjustment in renal impairment

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Peripheral neuropathy

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69. Seen w/ use of:

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Peripheral neuropathy

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70. Metronidazole – Isoniazid – Vincristine – ddI – AZT – Allopurinol

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Sulfonamides & newborns

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71. Kernicterus can occur

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“O.N.E.” for gonorrhea

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72. Fluoroquinolones used in a one dose deal for gonorrhea:

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“O.N.E.” for gonorrhea

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73. O = Ofloxacin 74. N = Norfloxacin 75. E = Enoxacin

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Ribavirin

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76. Txt RSV (Respiratory Syncytial Virus)