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Culture: selective media -- CCBA – charcoal-cephalexin blood agar; Bordet-Gengou, Regan-Lowe

This culture identifies what bug?
Bordetella pertussis
viruses in paramyxovirus family
mumps, rhinovirus, parainfluenza
virus in paramysoviridae family
rsv = respiratory syncytia virus
describe paramyxovirus infectious agent
neg sense ss rna virus. enveloped. f peplomer, h peplomer
describe paramysoviridae infectious agent
neg sense ss rna virus. enveloped. f peplomer, but NO h peplomer
How to Dx Parainfluenza Virus
Diagnosis:
Radiography (steeple sign)
Nasopharyngeal secretion – immunofluorescence – poor sensitivity
Serology - HAI; ELISA; Hemagglutination Assay
what is steeple sign
The subglottic tracheal
narrowing produces an
inverted V appearance
known as the steeple
sign (arrows).
Prominent intercostal or
sub-sternal retraction due
to airway obstruction is a sign of what disease
RSV bronchiolitis
VF of Bordetella pertussis
Filamentous hemagglutinin (FHA)
Pertactin - Adhesin
Pertussis toxin – also toxigenic
Infectious Agent Bordetella pertussis
Gram negative bacillus
toxins of bordetella pertussis
1. . Pertussis toxin (PTx) – adenosine diphosphate (ADP)-ribosyltransferase
PTx --| Gproteins --| adenyl cyclase --inc cAMP --dec recruitment of phagocytes
PTx leads to LYMPHOCYTOSIS, HYPOGLYCEMIA, INCREASED HISTAMINE SENSITIVITY
2. Lethal toxin or Dermonecrotic toxin (DNT) (Heat labile) – inactivates intracellular Rho GTPases
3. Tracheal Cytotoxin (Peptidoglycan subunit)
Interferes with DNA synthesis and triggers nitric oxide production, kills ciliated respiratory cells; increases IL-1; stimulates fever
whooping cough is caused by
bordetella pertussis
3 stages of whooping cough
1. Catarrhal (1-2 weeks): ~common cold; profuse rhinorrhea, sneezing, low grade fever; contagious
2. Paroxysmal (2-4 weeks): (coughing spasm) destruction of ciliated epithelium; impairment of mucous clearing; characteristic inspirational whoop following serious of coughs, vomiting, leukocytosis
3. Convalescent: May have secondary complications: Pneumonia, seizures, encephalopathy (disease brain)
lab dx for bordetella pertussis
catalase pos, oxidase pos, urease neg
dx for bordetella pertussis
Culture: selective media -- CCBA – charcoal-cephalexin blood agar; Bordet-Gengou, Regan-Lowe