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161 Cards in this Set
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Aids (def)
|
an infectious disease that is transmitted mainly by intimate/sexual contact and parenteral means by HIV
-CD4 lymphocyte count <200 |
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Is HIV commonly passed to health care workers?
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NO
|
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How many years can someone go w/out showing clinical signs of HIV
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10
|
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What type of virus is HIV? and what is the core genetic material
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Retrovirus
RNA is the core genetic material |
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Do you want a high or low CD4 count?
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HIGH, the more HIV the less CD4
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How early will a person develop antibodies for HIV
|
6-12wks
|
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What cell does HIV replicate in?
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T-helper cell
when that cell dies, the virus leaves and seeks out a new cell to infect |
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what is it called when people have mono-like symptoms, fever, lymphadenopathy, fatigue, mucocutaneous ulcers, pharyngitis, skin rash
(HIV related) what time frame does it happen within? |
Seroconversion sickness
2-4wks |
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what is the time of infection to time when symptoms of AIDS are evident called?
|
Incubation
(mean=10-12yrs) |
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Group 1/ Stage 1
(HIV) |
-Immediate
-Asymptomatic |
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Group 2/ Stage 2
(HIV) |
-HIV symptomatic stage
-SYMPTOMS show |
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Group 3/ Stage 3 (HIV)
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-have AIDS
-CD4 count <200 -opportunistic infections may be evident |
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What are the two ANTIBODY tests for HIV
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1. ELISA or EIA
2. Western Blot Test (if you have the antibody, you were exposed) *ELISA is taken first, high false(+) rate so then Western Blot test is done |
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what are the two HIV Antigen Tests?
Which one is more sensitive |
1. P24
2. PCR *P24 is more sensitive, can do before antibody test |
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What test measures HIV viral load?
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PCR
|
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Asymptomatic Stage 1
(HIV CD4 stages) |
-CD4 count 500-800 cells/mm3
-Asymptomatic |
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Early Symptomatic HIV Infection Stage 2
(HIV CD4 stages) |
-CD4 count 200-500
**START antiretroviral meds** |
|
Advanced HIV Infection Stage 3
(HIV CD4 stages) |
-CD4 count <200
-pt has AIDS -opportunistic infections -Neoplasms -Wasting Syndrome |
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What count gives you info about progression and stage of HIV?
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CD4
|
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What count tells you how active the HIV is?
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Viral Load
|
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What count tells you:
platelet count clotting time hemaglobiin WBC count |
CBC (Complete Blood Count)
|
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if CD4 count is 500, is pt on antiretrovirals?
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Pt doesn't have to be, it MAY BE indicated
|
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if CD4 count is 300-500, is pt on antiretrovirals?
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GENERALLY indicated
(early opportunistic infections) |
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if CD4 count is 200-300, is pt on antiretrovirals?
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INDICATED
(some major opportunistic infections) |
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if CD4 count is <200, what meds are needed?
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pt must PRE-MED and antiretrovirals
(AIDS dx) |
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How do we treat a pt w/a CD4 count >200?
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Normally
|
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When do you get a consultation based on CD4 count?
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<200
|
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What is the lowest detectable viral load for HIV?
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50 copies/ml
|
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What does the platelet count have to be to safely treat the patient?
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50,000
(CBC w/differential) |
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What drug slows down production of HIV and is good for newly infected cells?
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NRTIs
(Nucleotide Reverse Transcriptase Inhibitors) |
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What drug is used to block duplication and spread of HIV?
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NNRITIs
(Non-Nucleotide Reverse Transcriptase Inhibitors) |
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What drug keeps non-infectious virus from becoming infectious and is also good for LONG time infected cells?
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Protease Inhibitors
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What drug is used on HIV patients that aren't responding well?
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Nucleotides
|
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What drug doesn't let HIV virus attack cells?
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Fusion or Entry Inhibitors
|
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What is the name of the therapy that uses 2 of the nucleoside analogs combined w/a protease inhibitor, and what is the CD4 count when this therapy is started?
|
Current Therapy AKA
Triple Therapy AKA HAART CD4 count <500 |
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What is the most common opportunistic infection assoc w/HIV
|
Pneumocystitis Carinii Pneumonia
|
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What is it when HIV is resistant to 1 drug and may become resistant to another?
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Cross-resistance
|
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Malignant neoplasias of immature white blood cells. Cancer of the WBC's affecting the bone marrow and circulating
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Leukemia
-all types more common in MALES -ACUTE more common than chronic -Idiopathic |
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Where are the majority of WBC's produced?
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Bone Marrow
|
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What are immature WBC's called?
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Stem cells or blasts
|
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What form of Leukemia:
-most common in CHILDREN and <19 -Peak of incidence is 2-4yrs old -20 fold more common w/Down Syndrome |
Acute Lymphocytic Leukemia (ALL)
|
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What is the prognosis of ALL
|
VERY good
-remission rates 90% CURE rates 70% (prognosis is worse for adults, REMISSION can be achieved by CHEMO, but duration is SHORT) |
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What form of Leukemia:
-risk factor includes exposure to radiation and BENZENE -gen older pop (mean=63) -DEATH in 1-3mos if left untreated |
Acute Myelogenous Leukemia (AML)
-Prognosis: <60 good, >60 poor -<60 usually go into complete remission |
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When the number of blast cells is reduced and can no longer be detected the patient is said to be in ________?
(leukemia) |
Remission
|
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Tx of Leukemia 3 Phases
|
1. Induction (hit hard/induce state of remission)
2. Consolidation/Intensification (consolidate and kill rest of leukemic cells) 3. Remission (maintenance therapy/prevent remaining leukemic cells from expanding) |
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How many years of remission does a leukemic pt have to be in to be considered cured?
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5
|
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Places in the body that leukemic cells hide in and chemotherapeutics can't get to them are called what?
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Sanctuaries
(CNS and testes) |
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What form of Leukemia:
-related to familial inheritance -more common in Jewish, Russian, and Eastern Europe ancestry -rare in Asian and children -no cure |
Chronic Lyphocytic Leukemia (CLL)
|
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What are the 3 stages of CLL
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1. Stage A: 2 or fewer lymph nodes
2. Stage B: 3 or more lymph nodes 3. Stage C: anemia and thrombocytopenia and any #of lymph node GROUPS (2yr survival rate) |
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What form of Leukemia:
-progress chronic-crisis -60> -inc risk w/radiation exposure -poor prognosis (3.5yrs from time of diagnosis) |
Chronic Myeloid Leukemia (CML)
|
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Clinical Signs/Symptoms of ACUTE leukemias
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-sudden, severe
-death 1-3mos if untreated **POORER prognosis if not caught early** |
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Clinical Signs/Symptoms of CHRONIC leukemias
|
-onset INSIDIOUS (quiet)
-better prognosis -many are ASYMPTOMATIC |
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If the ct has severe neutropenia what do they have to do before being seen?
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Pre-med
|
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hereditary form of hemolytic anemia, resulting from defective hemoglobin molecule resulting in deoxygenated, crescent shaped erythrocytes
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Sickle Cell Anemia
|
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Etiologic factors of Sickle Cell
|
-African Americans
-white populations in the Mediterranean origin (protected ethnicity from Malaria) -genetically passed by carrier parents only -genetic code AS = trait -genetic code SS = Sickle Cell |
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What blood test is given to detect Sickle Cell?
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Hemoglobin Electrophoresis
|
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with sickle cell, what is it called when production of red blood cells STOP
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Aplastic Crisis
|
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This is the medical management of what disease?
-FOLATE supplements -vaccinate children -genetic counseling for those w/trait -stem-cell transplant -PCN pre-med first 5yrs of life |
Sickle Cell Anemia
|
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What drug is used to prevent cells from sickling?
|
Hyroxyurea
|
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What oral findings are there w/Sickle Cell anemia
|
-decreased radiodensity
-coarse trabecular pattern -sig bone loss in children |
|
These are Tx modifications for what disease:
-during crisis, emerg tx only -avoid long, complicated tx -local anesthetic w/out epi -avoid barbituates/strong narcotics -avoid liberal use of slicylates(aspirins) -use nitrous-oxide w/greater than 50% oxygen |
Sickle Cell Anemia
|
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Congenital bleeding disorder of one of the blood clotting factors
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Hemophilia
Inherited: genetically transferred Acquired: secondary to diseases |
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What type of hemophilia accounts for most hemophiliac patients?
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Hemophilia A (80-85%)
|
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What are the 3 Classifications of Hemophilia
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1. Hemophilia A (factor VIII deficiency)
2. Hemophilia B aka Christmas Disease (factor XI deficiency) 3. Von Willebrand's Disease (platelet adhesion) |
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4 Phases of Controlled Bleeding
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1. Vascular Phase (IMMEDIATELY after injury)
2. Platelet Phase (SECONDS after, mechanical plugs, becomes "sticky") 3. Coagulation Phase (MORE SLOWLY than other phases) 4. Fibrinolytic Phase (DISSOLVES blood clot) |
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What gene is Hemophilia A linked to?
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X-linked
(dad won't transmit to sons, but daughters will become carriers) |
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What Hemophilia is:
-most common -BEST known CLOTTING defect -affects males -apparent in childhood -bleeding seems to stop after injury RESUMES in 1hr |
Hemophilia A
|
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What hemophilia is:
-deficiency in factor IX -primarily manifests in males -female carriers (more rare) |
Hemophilia B (Christmas Disease)
|
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What hemophilia is:
-most common INHERITED bleeding disorder -1% of population -defect in PLATELET fx -affects males and females |
Von Willebrand's Disease
|
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This level of hemophilia have 1% of the clotting factor and BLEED SPONTANEOUSLY
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Severe
|
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This level of hemophilia
-hemorrhage ONLY w/TRAUMA -1x per MONTH |
Moderate
|
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This level of hemophilia:
-bleed only AFTER SEVERE INJURY and surgery |
Mild
|
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These are signs/symptoms of what disease?
-large, deep bruising -intramuscular bruising -HEMARTHROSES (bleeding into soft tissues/joints=pain) -severe complications include AIRWAY obstruction, intestinal obstruction, compression of nerves=paralysis |
Hemophilia
|
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What 3 bleeding areas are life threatening w/hemophilia?
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-head
-throat -gut |
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what are the 4 Factor Replacement therapies for Hemophilia
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1. Whole Blood
2. Plazma 3. Cryoprecipitate 4. Factor Concentrates |
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Why is Whole Blood replacement therapy difficult?
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-must be fresh
-compatible -need large volumes -may overload body=stop heart |
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What is the best factor replacement therapy? Why?
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Factor Concentrate
b/c: -made from human blood or manufactured -VERY EFFECTIVE (expensive, safety depends on methods) |
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What meds should hemophiliacs avoid and why?
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aspirin/NSAIDS
b/c they THIN BLOOD |
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What is the best screening test for hemophilia?
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PTT (Partial Thromboplastin Time)
|
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What screen test is used to screen for possible bleeding problems b/c of THROMBOCYTOPENIA?
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Platelet Count
|
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What test measures platelet fx?
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Platelet Function Analyzer 100
|
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What test is used to screen for inherited disorders of platelet fx (how long it takes to stop bleeding after fresh cut)
|
Ivy Bleeding Time
|
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Cancer of the lyphoid organs and tissues
(grouped as B-cell and T-cell neoplasms) |
Lymphomas
|
|
What is the name of the lymphoma that:
-is an ORDERLY SPREAD from 1 lymph node to another -affects any age group -2 peaks in life (1 early, 1 in the 5th decade) -mostly males -firm, NON-TENDER, enlarged lymph node UPPER body (neck, underarms, chest) |
Hodgkin's
|
|
What is the etiology of Hodgkin's disease
|
unknown
|
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What virus is generally present w/Hodgkin's disease
|
Ebstein-Barr
|
|
What disease are these signs/symptoms
-fever -BONE PAIN -weigh loss -night sweats -ENLARGED lymph nodes of UNDERARM/GROIN area -PAIN following ALCOHOL consumption |
Hodgkin's Disease
|
|
What are the 4 Stages of tx for Hodgkin's disease
|
Stage 1: 1 lymph node or 1grp
RADIOTHERAPY only Stage 2: 2+grps on ONE side of diaphragm RADIOTHERAPY only Stage III: involvement of lymph nodes on BOTH sides of diaphragm RADIOTHERAPY or CHEMO Stage IV: Diffuse CHEMO |
|
How early do patients RELAPSE w/Hodgkin's disease
|
2yrs
(5yr survival in earlier stages 90% later stages 60%) |
|
What lymphoma
-B-cells more commonly affected -5th most common cancer in females, 6th in males -time of dx is 67, more common -prognosis is gen poor chemo or radation |
Non-Hodgkin's
|
|
what disease are these signs/symptoms of
-TENDER lymph nodes |
Non-Hodgkin's
|
|
What type of Lymphoma:
-AGGRESSIVE of B-cell origin -one of the most CURABLE lymphomas -Endemic to Central Africa -tx=HIGH DOSE CHEMO -if live past 2yrs, enjoy long-term remission |
Burkitt's Lymphoma
|
|
Type of Burkitt's
-found in Africa -related to EBV -HIGH chance of involving jaw -commonly involves abdomen |
Endemic Burkitt's Lymphoma
|
|
Type of Burkitt's
-common in rest of world -BONE MARROW common -RARE jaw involvement -90% of abdomens in children |
Sporadic Burkitt's Lymphoma
|
|
What disease are these oral manifestations of?
-Waldeyer's Ring: erythematous swelling w/surface ulcerations as result of trauma (may involve pharynx, palate, tongue, gingiva, lips) -Herpes Zoster -Herpetic Stomatitis -Oral Candidiasis |
Lymphoma
|
|
What tx involves use of chemical agents in order to destroy/deactivate cancer cells
|
Chemotherapy
|
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What two terms are used to describe chemotherapy
|
1. Antineoplastic (anti-cancer)
2. Cytotoxic (cell killing) |
|
What are the 2 main uses of chemotherapy
|
1. reduce size of lesion and destroy cancer cells
2. After surgery, kill cancer cells that may have spread throughout body |
|
3 Possible Chemotherapy GOALS
|
1. Cure
2. Control 3. Palliation (relieve symptoms of cancer) |
|
What are the 2 Protocols for Chemotherapy
|
1. Cycle: 1 time/1 round schedule
2. Course: ALL cycles in entire tx |
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What type of chemotherapy is used BEFORE SURGERY or radiation to shrink the tumor/growth
|
Neoadjuvant
|
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What type of chemotherapy is used AFTER surgery or radiation
|
Adjuvant
|
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What HEALTHY cells does chemotherapy commonly affect
|
-skin
-lining of stomach -intestines -bladder |
|
What are common side effects of chemo
|
-nausea/vomitting
-Retching -appetite loss (anorexia) -Alopecia (hair loss) -possible weight gain -Esophagitis -Mucositis: inflam of mucous membrane lining ENTIRE DIGESTIVE TRACT (from mouth to rectum) |
|
Blood related side effects of chemotherapy
|
-bone marrow suppression (DEC RBC's, WBC's, platelets)
-Nadir: time when blood components are at their lowest (1-2wks after chemo starts) Anemia: low RBC's Neutropenia: low WBC's Thrombocytopenia: low platelets |
|
What is the common sign of neutropenia
|
"shake & bake"
fever-->chills (ck temp 1-2xday, if >100 call dr |
|
Signs of Thrombocytopenia
|
-easy bruising
-bleeding from skin doesn't stop -INTERNAL BLEEDING |
|
how many days after chemo is started should you treat the pt
|
7-20days
|
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What type of cancer therapy uses electromagnetic radiation in order to destroy cancer cells
|
Radiation Therapy
|
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What are the 3 types of beams used for radiation therapy
|
1. External Beam Therapy
2. Internal: Interstitial Implant, Brachytherapy 3. Systemic Radiation Therapy |
|
What type of radiation therapy:
-usually given on outpatient basis -treat most types of cancer -beam generated OUTSIDE targeted at tumor site |
EBT (External Beam Therapy)
|
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What type of radiation therapy:
-place radioactive material INSIDE body -temporary or permanent |
Internal Beam
|
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What type of radiation therapy
-radioactive material taken BY MOUTH or INJECTED -tx for thyroid, non-hodgkins lymphoma |
Systemic
|
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What time of leukemia can be cured
|
Acute
|
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what disease is caused by permanent damage to bone and blood supply, characterized by exposed bone that fails to heal after high-dose radiation in the jaws
|
Osteoradionecrosis (ORN)
|
|
what complication is treated by:
-mouth rinse w/Salt and Sodium Bicarbonate. -cocktail of Benadryl and lidocaine -Milk of Magnesia |
Mucositis
(dentures should NOT be worn until acute phase has resolved) |
|
What med is given for herpetic infenctions
|
Acyclovir
|
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What form of fl should be used for radiated pt
|
Fl Gel for sensitivity
|
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what is the most common secondary infection w/radiated patients
|
Pseudomembranous Candidiasis
|
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What drug effects healing and causes bone problems (jaw) in radiated patients
-taken for osteoperosis |
Bisphosphonate
|
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What is the other name for Down Syndrome
|
mongolism
|
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What chromosome does Down Syndrome effect
|
Chromosome 21 (trisomy 21)
|
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What condition are these signs/symptoms of:
-Hypotonia (overall growth retardation) -Microcephaly (small head) -Strabismus (convergent eyes) -Simian Crease (single palmar crease) |
Down Syndrome
|
|
What are pt w/Down Syndrome more at risk for
|
Leukemia (20x)
|
|
What condition are these oral findings related to:
-Prognathism -Protrusive, fissured tongue (tongue thrust) -DEC salivary flow -Microdontia -Enamel Dyslplasia -Malocclusion -Macroglossia -Taurodontism |
Down Syndrome
|
|
What are oral health care precautions should be taken w/Down Syndrome
|
-Med Consult
-Excessive Gag reflex -Antibiotic premed for heart defects -consult for nitrous-oxide |
|
What condition refers to:
a collection of neurologically-based developmental disorders in which individuals have impairments in social interaction and communication skills |
Autism
|
|
What type of disorder is Autism considered to be
|
Sprectum Disorder
|
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What sex is autism more common in and when does it appear
|
4x more common in MALES
appears w/in first 3yrs |
|
What type of Autism is ONLY found in GIRLS?
|
Rett's Disorder
|
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What condition are these signs/symptoms of:
-communication-language develops slow or never -Echolalia (parrot-like repitition) -difficulty w/change |
Autism
|
|
What condition is:
-IQ below 70 -Sub-average intellectual fx |
Mental Retardation
|
|
What are the 4 stages of Mental Retardation
|
1. Mild
2. Moderate 3. Severe 4. Profound |
|
What stage of mental retardation is
-Educable -6th grade academic ability |
Mild
Mental Retardation |
|
What stage of mental retardation is:
-trainable -2nd grade academic ability -good self-care skills -jobs w/supervision |
Moderate
Mental Retardation |
|
What stage of mental retardation is:
-CUSTODIAL -ongoing, consistent levels of support -BASIC self care -CLOSE supervision -Group homes or live w/family |
Severe
Mental Retardation |
|
What stage of mental retardation is:
-Custodial -HIGH level of support for ADL |
Profound
Mental Retardation |
|
What type of factors are these regarding mental retardation
-Chromosomal abnormalities -Congenital factors -Genetic neurologic disorders -malnutrition |
Prenatal factors
|
|
What type of factors are these regarding mental retardation
-Prematurity -CNS bleeding -Breech or High Forceps delivery -Preeclampsia (sudden high BP) |
Perinatal Factors
|
|
What type of factors are these regarding mental retardation
-Viral/bacterial Encephalitides -Lead and Mercury Poisoning -SEVERE malnutrition -HEAD INJURIES -Asphysxia |
Postnatal Factors
|
|
4 Levels of Mental Retardation
|
Level A: severe
Level B: moderate Level C: mild Level D: normal |
|
What condition are these signs/symptoms of:
-difficulty in learning/applying -Microcephaly (small head) -Hydrocephaly (expansion of the cranium) |
Mental Retardation
|
|
What condition are these oral manifestations assoc with?
-Higher prevalence of perio -higher incidence of malocclusion and deviations (may be some physical self-abuse) |
Mental Retardation
|
|
What are some special considerations for mental retardation
|
Tell-show-do
-direct communication -warm,friendly atmosphere -Nitrous Oxide |
|
What condition is
-most common form of Dimentia -brain shrinks as gap develops -progressive, irreversible brain disorder -no gender/race prevalence |
Alzheimer's Disease
|
|
What is the etiology for Alzheimer's disease
|
not certain
-age and family hx possible |
|
What condition are these signs/symptoms for
-memory loss affects job -difficulty performing familiar tasks -disorientation w/time and place -change in personality |
Alzheimer's Disease
|
|
4 Stages of Alzheimer's Disease
|
1. Early Stage
2. Middle Stage 3. Advanced Stage 4. Terminal Stage |
|
What stage of Alzheimer's Disease is:
-forgetfullness -personality changes -work performance difficulty -social withdrawal -errors in judgment |
Early stage
|
|
What stage of Alzheimer's is:
-Disorientation -loss of coordination -progressive memory loss -terrible/sudden disaster reactions (b/c of loss of time) |
Middle Stage
|
|
What stage of Alzheimer's is:
-Profound comprehension difficulty -bowel incontinence -seizures -inability to recognize family -aggression |
Advanced Stage
|
|
What stage of Alzheimer's is:
-physical IMMOBILITY -difficulty swallowing -mutism -unaware of surroundings -total helplessness |
Terminal Stage
|
|
What are the 4 FDA approved drugs for Alzheimer's and when do they have to be started to work
|
1. Cognex
2. Atricept 3. Exelon 4. Reminyl have to start them EARLY |
|
What condition is this tx plan appropriate for:
-short appt -best in morning, not dark -don't treat like child -DHE short/simple -sedation may be necessary -3-sided toothbrush -tell them it's "non-gagging" -explain EVERYTHING -put cotton rolls on instruments to trick them |
Alzheimer's Diseasee
|
|
What condition can result from:
any structural/functional cardiac disorder that impairs the ability of the ventricle to fill with/eject blood |
Congestive Heart Failure (CHF)
|
|
What is the most common cause of death in the US
|
Congestive Heart Failure
(more common in elderly, 5% <40) |
|
These are the most common causes of what condition:
-Coronary artery disease -hypertension -cardiomyopathy(enlarged heart) -infective endocarditis -valvular heart disease -pulmonary embolism -endocrine disease |
CHF
|
|
These are the signs/sympoms of what disease:
-Rapid/Shallow breathing -Cheyne-Stokes respiration (periodic breathing shallow to deep) -Inspiratory Rales (crackling) -Gallop rhythm -Heart murmur -Ascites (fluid accumulates in abdomen) |
CHF
|
|
What are the 3 stages of CHF
|
1. First stage: ventricular dysfunction, development of gallop rhythm
2. Second stage: dyspnea, pulmonary congestion, peripheral edema 3. Third stage: compensated heart failure |
|
4 Classes of CHF
|
Class I: no limitation, no problems
Class II: Slight limitation, fatigue , palpitations, but COMFORTABLE AT REST Class III: MARKED limitation of activity, less than ordinary physical activity, COMFORTABLE at REST Class IV: symptoms PRESENT at REST |
|
what 4 Treatments are used for CHF
|
1. ACE inhibitors **MOST IMPORTANT when fighting CHF
2. Diuretics: given w/other meds (lowers BP) 3. Beta Blockers: prevent adrenaline from binding to heart cells (slows heart rate) 4. Inotropes: INC strength of heart's contractions (prescribe ACE inhibitors before inotropes) |