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15 Cards in this Set
- Front
- Back
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What is nitric oxide?
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An intracellular and intercellular messenger
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How is nitric oxide formed?
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product of a reaction catalyzed by endothelial nitric oxide synthase (eNOS) substrate being L-arginine
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When is nitric oxide produced in the cardiovascular system?
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In response to:
1)Pharmacological control (bradykinin, histamine, and acetylcholine on endothelium) 2)Hypoxia 3)Stress (pressure on vessels) |
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What is the "story" of nitric oxide?
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Increase in biosynthesis of NO -> increased [NO] -> Activates enzyme guanylate cyclase -> catalyzes the conversion of GTP to cGMP -> increases [cGMP]-> elevated levels of cGMP intracellularly prevents the Ca++ channel from opening -> decreases [Ca++] -> not enough Ca++ to allow for vascular contraction (smooth muscle) -> decreased peripheral resistance and increased delivery of oxygen to the myocardial tissues
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What is the end result of Nitric oxide mechanism?
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Angina -> increases O2 to heart via vasodilation
HTN -> decrease peripheral resistance via vasodilation |
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What is the influence of CCBs on endogenous NO production?
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Promote release of NO from vascular endothelium
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What is the influence of ACE inhibitors on endogenous NO production?
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Bradykinin stimulates endothelium to relase vasodilators including NO
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What is the influence of HMG CoA Reductase Inhibitors on endogenous NO production?
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Stabilize nitric oxide synthetase, leads to increase in NO production
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What is the MOA of phosphodiesterase inhibitors?
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Increases cAMP which relaxes smooth muscle and contracts cardiac muscle
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What is the name of the natural product derived from opium?
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Papaverine
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What are the MOAs of Hydralazine?
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1) Activator of guanylate cyclase
2) Interferes with calcium entry and relase from intracellular stores |
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What are the MOAs of Dipyridamole?
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1) Adenosine deaminase inhibitor (adenosine is an inhibitor of PDE)
2)Phosphodiesterase inhibitor |
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What is the name of the natural product derived from opium?
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Papaverine
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What are the MOAs of Hydralazine?
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1) Activator of guanylate cyclase
2) Interferes with calcium entry and relase from intracellular stores |
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What are the MOAs of Dipyridamole?
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1) Adenosine deaminase inhibitor (adenosine is an inhibitor of PDE)
2)Phosphodiesterase inhibitor |
