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15 Cards in this Set

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What is nitric oxide?
An intracellular and intercellular messenger
How is nitric oxide formed?
product of a reaction catalyzed by endothelial nitric oxide synthase (eNOS) substrate being L-arginine
When is nitric oxide produced in the cardiovascular system?
In response to:
1)Pharmacological control (bradykinin, histamine, and acetylcholine on endothelium)

2)Hypoxia

3)Stress (pressure on vessels)
What is the "story" of nitric oxide?
Increase in biosynthesis of NO -> increased [NO] -> Activates enzyme guanylate cyclase -> catalyzes the conversion of GTP to cGMP -> increases [cGMP]-> elevated levels of cGMP intracellularly prevents the Ca++ channel from opening -> decreases [Ca++] -> not enough Ca++ to allow for vascular contraction (smooth muscle) -> decreased peripheral resistance and increased delivery of oxygen to the myocardial tissues
What is the end result of Nitric oxide mechanism?
Angina -> increases O2 to heart via vasodilation

HTN -> decrease peripheral resistance via vasodilation
What is the influence of CCBs on endogenous NO production?
Promote release of NO from vascular endothelium
What is the influence of ACE inhibitors on endogenous NO production?
Bradykinin stimulates endothelium to relase vasodilators including NO
What is the influence of HMG CoA Reductase Inhibitors on endogenous NO production?
Stabilize nitric oxide synthetase, leads to increase in NO production
What is the MOA of phosphodiesterase inhibitors?
Increases cAMP which relaxes smooth muscle and contracts cardiac muscle
What is the name of the natural product derived from opium?
Papaverine
What are the MOAs of Hydralazine?
1) Activator of guanylate cyclase

2) Interferes with calcium entry and relase from intracellular stores
What are the MOAs of Dipyridamole?
1) Adenosine deaminase inhibitor (adenosine is an inhibitor of PDE)

2)Phosphodiesterase inhibitor
What is the name of the natural product derived from opium?
Papaverine
What are the MOAs of Hydralazine?
1) Activator of guanylate cyclase

2) Interferes with calcium entry and relase from intracellular stores
What are the MOAs of Dipyridamole?
1) Adenosine deaminase inhibitor (adenosine is an inhibitor of PDE)

2)Phosphodiesterase inhibitor