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11 Cards in this Set
- Front
- Back
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Thyroid Gland
Located? |
Located?
just below the larynx, anterior to the trachea Two lobes and an isthmus |
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Thyroid Hormone
Metabolism in ______, also in the ______ |
Metabolism in liver, also in the brain
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Thyroid Hormone
Regulated by? |
Regulated by?
the pituitary hormone, thyrotropin, in a negative feedback loop |
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Thyroid Hormone
Binding to ? |
Actions mediated by binding to?
nuclear thyroid receptors to modulate transcription of specific genes |
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Thyroid Hormones
Synthesis? |
Thyroid Hormones
Synthesis—uptake of iodide by gland, oxidation and iodination |
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Effects of Thyroid Hormones
Calorigenic - Basal metabolic rate. |
Effects of Thyroid Hormones
Calorigenic - increase Basal metabolic rate. |
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Effects of Thyroid Hormones
Sympathomimetic effects - tissue responses to catecholamines |
Effects of Thyroid Hormones
Sympathomimetic effects - increase tissue responses to catecholamines |
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Effects of Thyroid Hormones
Metabolic — _____ lipolysis, ____ protein catabolism ____ LDL |
Metabolic —
increase lipolysis, decrease protein catabolism Increase LDL |
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Measurement of plasma hormones???
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A. Measurement of plasma hormones
1. T3, T4, TSH (RIA, Enzyme immunoassay) |
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TSH stimulation test - distinguishes???
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TSH stimulation test - distinguishes 1o vs. 2o hypothyroidism (or simply measure TSH)
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Hypothyroidism (myxedema coma, severe)
Sumptoms? |
Hypothyroidism (myxedema coma, severe)
1. Symptoms a. mental retardation (cretinism) in infants b. decrease BMR, cold intolerance, slow mentation (speed of cognitive operations) , slow speech, bradycardia, lethargy, weight gain, ↓ growth (children) |
